TY - JOUR
T1 - Multiple pesticide analysis in hair samples of pregnant French women
T2 - Results from the ELFE national birth cohort
AU - Béranger, Rémi
AU - Hardy, Emilie M.
AU - Dexet, Célia
AU - Guldner, Laurence
AU - Zaros, Cécile
AU - Nougadère, Alexandre
AU - Metten, Marie Astrid
AU - Chevrier, Cécile
AU - Appenzeller, Brice M.R.
N1 - Funding Information:
ELFE is a study conducted conjointly by the National Institute of Demographic Studies (Ined), the French National Institute for Health and Medical Research (Inserm), French blood agency (EFS), French Institute for Public Health Surveillance (InVS), French National Institute for Statistics and Economic Studies (Insee), the General Directorate for Health (DGS, Ministry of Health), General Directorate for Risk Prevention (DGPR, Ministry of Environment), the Directorate for Research, Studies, Evaluation and Statistics (Drees), and the French National Family Allowance Fund (Cnaf). It receives additional funding from the Ministry of Research Committee on the humanities and social sciences (CCDSHS), and the Ministry of Culture and Communication (Deps). As part of the RECONAI platform, ELFE also receives funding from the National Research Agency (ANR-11-EQPX-0038).
Funding Information:
The authors would like to thank all the participants, the midwives who participated in recruiting women and collecting biological samples, and the ELFE team. We also thank G. Bouvier, J. Caudeville, C. Dereumeaux and M. Hulin for their participation in the selection of the pesticides of interest, and J.A. Cahn for editorial assistance. R. Beranger held a post-doctoral fellow from the Fondation de France (ref. R15158NN) and was supported by the Fondation Mustela (under the aegis of the Fondation de France). This project was funded by the French Agency for Food, Environmental and Occupational Health & Safety (grant PNR EST-13-138 ). This grant was supervised by the French Ministry of Agriculture, with the financial support of the French Agency for Biodiversity, based on funding from taxes on diffuse pollution attributed to the Ecophyto plan.
Publisher Copyright:
© 2018 Elsevier Ltd
PY - 2018/11
Y1 - 2018/11
N2 - Background: A growing body of evidence suggests that prenatal exposure to pesticides might impair fetal development. Nonetheless, knowledge about pesticide exposure of pregnant women, especially in Europe, is largely restricted to a limited panel of molecules. Aim: To characterize the concentration of 140 pesticides and metabolites in hair strands from women in the ELFE French nationwide birth cohort. Methods: Among cohort members who gave birth in northeastern and southwestern France in 2011, we selected those with a sufficient available mass of hair (n = 311). Bundles of hair 9 cm long were collected at delivery. We screened 111 pesticides and 29 metabolites, including 112 selected a priori based on their reported usage or detection in the French environment. The bundles of hair from 47 women were split into three segments to explore the intraindividual variability of the exposure. Intraclass correlation coefficients (ICCs) were computed for the chemicals with a detection frequency >70%. Results: We detected a median of 43 chemicals per woman (IQR 38–47). Overall, 122 chemicals (>20 chemical families) were detected at least once, including 28 chemicals detected in 70–100% of hair samples. The highest median concentrations were observed for permethrin (median: 37.9 pg/mg of hair), p-nitrophenol (13.2 pg/mg), and pentachlorophenol (10.0 pg/mg). The ICCs for the 28 chemicals studied ranged from 0.59 to 0.94. Conclusion: Pregnant women are exposed to multiple pesticides simultaneously from various chemical families, including chemicals suspected to be reproductive toxicants or endocrine disruptors. The ICCs suggest that the intraindividual variability of pesticide concentrations in hair is lower than its interindividual variability.
AB - Background: A growing body of evidence suggests that prenatal exposure to pesticides might impair fetal development. Nonetheless, knowledge about pesticide exposure of pregnant women, especially in Europe, is largely restricted to a limited panel of molecules. Aim: To characterize the concentration of 140 pesticides and metabolites in hair strands from women in the ELFE French nationwide birth cohort. Methods: Among cohort members who gave birth in northeastern and southwestern France in 2011, we selected those with a sufficient available mass of hair (n = 311). Bundles of hair 9 cm long were collected at delivery. We screened 111 pesticides and 29 metabolites, including 112 selected a priori based on their reported usage or detection in the French environment. The bundles of hair from 47 women were split into three segments to explore the intraindividual variability of the exposure. Intraclass correlation coefficients (ICCs) were computed for the chemicals with a detection frequency >70%. Results: We detected a median of 43 chemicals per woman (IQR 38–47). Overall, 122 chemicals (>20 chemical families) were detected at least once, including 28 chemicals detected in 70–100% of hair samples. The highest median concentrations were observed for permethrin (median: 37.9 pg/mg of hair), p-nitrophenol (13.2 pg/mg), and pentachlorophenol (10.0 pg/mg). The ICCs for the 28 chemicals studied ranged from 0.59 to 0.94. Conclusion: Pregnant women are exposed to multiple pesticides simultaneously from various chemical families, including chemicals suspected to be reproductive toxicants or endocrine disruptors. The ICCs suggest that the intraindividual variability of pesticide concentrations in hair is lower than its interindividual variability.
KW - Environmental monitoring
KW - Hair
KW - Maternal exposure
KW - Pesticides
UR - http://www.scopus.com/inward/record.url?scp=85050611977&partnerID=8YFLogxK
U2 - 10.1016/j.envint.2018.07.023
DO - 10.1016/j.envint.2018.07.023
M3 - Article
C2 - 30064054
AN - SCOPUS:85050611977
SN - 0160-4120
VL - 120
SP - 43
EP - 53
JO - Environment international
JF - Environment international
ER -