Multiple mechanisms for hydrogen peroxide-induced apoptosis

Claudia Cerella; Simona Coppola; Vittoria Maresca; Milena De Nicola; Flavia Radogna; Lina Ghibelli

doi:10.1111/j.1749-6632.2009.04901.x

Multiple mechanisms for hydrogen peroxide-induced apoptosis

Claudia Cerella, Simona Coppola, Vittoria Maresca, Milena De Nicola, Flavia Radogna, Lina Ghibelli^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

28 Citations (Scopus)

Abstract

The mechanisms of cell killing by oxidative stress, in particular by hydrogen peroxide, are not yet well clarified. Here, we show that during recovery after H₂O₂ treatment, apoptosis occurs in two different waves, peaking at 8 h (early) and 18 h (late) of recovery from oxidative stress. The two peaks are differentially modulated by a set of inhibitors of metabolic processes, which suggests that the first peak depends on DNA break formation, whereas the second may be correlated with H ₂O₂-induced mitochondrial alterations.

Original language	English
Title of host publication	Natural Compounds and Their Role in Apoptotic Cell Signaling Pathways
Publisher	Blackwell Publishing Inc.
Pages	559-563
Number of pages	5
ISBN (Print)	9781573317375
DOIs	https://doi.org/10.1111/j.1749-6632.2009.04901.x
Publication status	Published - Aug 2009
Externally published	Yes

Publication series

Name	Annals of the New York Academy of Sciences
Volume	1171
ISSN (Print)	0077-8923
ISSN (Electronic)	1749-6632

Keywords

ADP-ribosylation
Apoptosis
Hydrogen peroxide

Access to Document

10.1111/j.1749-6632.2009.04901.x

Cite this

Cerella, C., Coppola, S., Maresca, V., De Nicola, M., Radogna, F., & Ghibelli, L. (2009). Multiple mechanisms for hydrogen peroxide-induced apoptosis. In Natural Compounds and Their Role in Apoptotic Cell Signaling Pathways (pp. 559-563). (Annals of the New York Academy of Sciences; Vol. 1171). Blackwell Publishing Inc.. https://doi.org/10.1111/j.1749-6632.2009.04901.x

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title = "Multiple mechanisms for hydrogen peroxide-induced apoptosis",

abstract = "The mechanisms of cell killing by oxidative stress, in particular by hydrogen peroxide, are not yet well clarified. Here, we show that during recovery after H2O2 treatment, apoptosis occurs in two different waves, peaking at 8 h (early) and 18 h (late) of recovery from oxidative stress. The two peaks are differentially modulated by a set of inhibitors of metabolic processes, which suggests that the first peak depends on DNA break formation, whereas the second may be correlated with H 2O2-induced mitochondrial alterations.",

keywords = "ADP-ribosylation, Apoptosis, Hydrogen peroxide",

author = "Claudia Cerella and Simona Coppola and Vittoria Maresca and {De Nicola}, Milena and Flavia Radogna and Lina Ghibelli",

year = "2009",

month = aug,

doi = "10.1111/j.1749-6632.2009.04901.x",

language = "English",

isbn = "9781573317375",

series = "Annals of the New York Academy of Sciences",

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booktitle = "Natural Compounds and Their Role in Apoptotic Cell Signaling Pathways",

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Multiple mechanisms for hydrogen peroxide-induced apoptosis. / Cerella, Claudia; Coppola, Simona; Maresca, Vittoria et al.
Natural Compounds and Their Role in Apoptotic Cell Signaling Pathways. Blackwell Publishing Inc., 2009. p. 559-563 (Annals of the New York Academy of Sciences; Vol. 1171).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Multiple mechanisms for hydrogen peroxide-induced apoptosis

AU - Cerella, Claudia

AU - Coppola, Simona

AU - Maresca, Vittoria

AU - De Nicola, Milena

AU - Radogna, Flavia

AU - Ghibelli, Lina

PY - 2009/8

Y1 - 2009/8

N2 - The mechanisms of cell killing by oxidative stress, in particular by hydrogen peroxide, are not yet well clarified. Here, we show that during recovery after H2O2 treatment, apoptosis occurs in two different waves, peaking at 8 h (early) and 18 h (late) of recovery from oxidative stress. The two peaks are differentially modulated by a set of inhibitors of metabolic processes, which suggests that the first peak depends on DNA break formation, whereas the second may be correlated with H 2O2-induced mitochondrial alterations.

AB - The mechanisms of cell killing by oxidative stress, in particular by hydrogen peroxide, are not yet well clarified. Here, we show that during recovery after H2O2 treatment, apoptosis occurs in two different waves, peaking at 8 h (early) and 18 h (late) of recovery from oxidative stress. The two peaks are differentially modulated by a set of inhibitors of metabolic processes, which suggests that the first peak depends on DNA break formation, whereas the second may be correlated with H 2O2-induced mitochondrial alterations.

KW - ADP-ribosylation

KW - Apoptosis

KW - Hydrogen peroxide

UR - http://www.scopus.com/inward/record.url?scp=69149103207&partnerID=8YFLogxK

U2 - 10.1111/j.1749-6632.2009.04901.x

DO - 10.1111/j.1749-6632.2009.04901.x

M3 - Conference contribution

C2 - 19723104

AN - SCOPUS:69149103207

SN - 9781573317375

T3 - Annals of the New York Academy of Sciences

SP - 559

EP - 563

BT - Natural Compounds and Their Role in Apoptotic Cell Signaling Pathways

PB - Blackwell Publishing Inc.

ER -

Multiple mechanisms for hydrogen peroxide-induced apoptosis

Abstract

Publication series

Keywords

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