Multifocal dysembryoplastic neuroepithelial tumor with signs of atypia after regrowth

Jens Schittenhelm*, Michel Mittelbronn, Markus Wolff, Jochen Truebenbach, Bernd E. Will, Richard Meyermann, Rudi Beschorner

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)


We report the case of a multifocal dysembryoplastic neuroepithelial tumor (DNT) in a 7-year-old girl with local tumor regrowth 6 years later. The tumor was localized in the right parietal lobe extending from the cortex into the periventricular white matter. After subtotal resection of a histopathologically confirmed DNT we observed unexpected tumor progression in long-term follow-up. Therefore, a second surgery was performed when the patient was 14 years of age. In neuropathological examination of the second specimen the tumor showed an increased cellularity and pleomorphism, microvascular proliferations, an elevated proliferative activity (MIB1-index focally up to 10%) and cellular atypia not typical for WHO grade I DNT. Furthermore, MRI studies showed additional supratentorial and infratentorial lesions which remained stable over years and are also well consistent with DNTs. Thus, an unusual form of a DNT with multifocal lesions, local regrowth and morphological transformation is supposed.

Original languageEnglish
Pages (from-to)383-389
Number of pages7
Issue number4
Publication statusPublished - Aug 2007
Externally publishedYes


  • Atypia
  • DNT
  • Multifocal
  • Proliferation
  • Regrowth


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