MOZ/TIF2-induced acute myeloid leukaemia in transgenic fish

Julia Zhuravleva, Jérôme Paggetti, Laurent Martin, Arlette Hammann, Eric Solary, Jean Noël Bastie, Laurent Delva*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

65 Citations (Scopus)

Abstract

The inv(8)(p11q13) chromosomal abnormality, described in acute myeloid leukaemias (AML), fuses the histone acetyl-transferase (HAT) MYST3 (MOZ) gene with another HAT gene, NCOA2 (TIF2). We generated a transgenic zebrafish in which the MYST3//NCOA2 fusion gene was expressed under control of the spi1 promoter. An AML developed in 2 of 180 MYST3/NCOA2-EGFP-expressing embryos, 14 and 26 months after injection of the fusion gene in a one-cell embryo, respectively. This leukaemia was characterised by an extensive invasion of kidneys by myeloid blast cells. This model, which is the first zebrafish model of AML, demonstrates the oncogenic potency of MYST3/NCOA2 fusion gene.

Original languageEnglish
Pages (from-to)378-382
Number of pages5
JournalBritish Journal of Haematology
Volume143
Issue number3
DOIs
Publication statusPublished - Nov 2008
Externally publishedYes

Keywords

  • Acute myeloid leukaemia
  • Animal model
  • Histone acetyl-transferase
  • MYST3/NCOA2
  • Zebrafish

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