Mono- and sesquiterpenoids, flavonoids, lignans, and other miscellaneous compounds of abies georgei

Xian Wen Yang, Yong Li Li, Su Mei Li, Yun Heng Shen, Jun Mian Tian, Zhi Jun Zhu, Lin Feng, Liang Wu, Sheng Lin, Ning Wang, Yonghong Liu, Wei Dong Zhang*

*Corresponding author for this work

    Research output: Contribution to journalArticleResearchpeer-review

    20 Citations (Scopus)

    Abstract

    A systematic phytochemical investigation of the aerial parts of Abies georgei yielded nine new and 72 known compounds, including four monoterpenes, four sesquiterpenes, 25 flavonones, 14 lignans, and 34 other chemical constituents. The new compounds included two monoterpenes (1 and 2), two sesquiterpenes (3 and 4), three flavonones (5, 6, and 7), and two other components (8 and 9). Their chemical structures were established on the basis of various spectroscopic data. All the isolates were tested for antitumor and anti-inflammatory activities. The new compound 9,4-dihydroxy-5,7-dimethoxy-8- methylchalcone (7) demonstrated a moderate antiproliferative effect on QGY-7703 tumor cells (IC17.6g/mL). The known compound isoferulaldehyde (67) exhibited the strongest inhibitory activity against lipopolysaccharide (LPS)-induced NO production in RAW 264.7 macrophages (IC19.0g/mL). Abies georgei may be a significant source of beneficial pharmaceutical compounds.

    Original languageEnglish
    Pages (from-to)742-748
    Number of pages7
    JournalPlanta Medica
    Volume77
    Issue number7
    DOIs
    Publication statusPublished - 2011

    Keywords

    • Abies georgei
    • Pinaceae
    • antitumor
    • flavonones
    • monoterpenes
    • nitric oxide (NO)
    • sesquiterpenes

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