Monitoring of measles elimination using molecular epidemiology

Mick N. Mulders; Anh T. Truong; Claude P. Muller

doi:10.1016/S0264-410X(00)00453-9

Monitoring of measles elimination using molecular epidemiology

Mick N. Mulders, Anh T. Truong, Claude P. Muller

Research output: Contribution to journal › Article › Research › peer-review

37 Citations (Scopus)

Abstract

The different measles virus genotypes are confined to more or less distinct geographic regions. Molecular characterization of virus isolates has been successfully used to determine epidemiological links between cases and the geographic origin of imported viruses. In Europe, indigenous measles has been eliminated in some countries, but in others the disease is still endemic. Intra-outbreak variability can be used to differentiate between sporadic endemic cases and a 'pseudo-outbreak' of unrelated imported cases. The interruption of virus circulation by mass vaccination campaigns could be demonstrated by comparing the variability of pre-campaign viruses with post-campaign isolates. Simplified tools are being developed that could bring genotyping within reach of laboratories that do not have the possibility of sequencing.

Original language	English
Pages (from-to)	2245-2249
Number of pages	5
Journal	Vaccine
Volume	19
Issue number	17-19
DOIs	https://doi.org/10.1016/S0264-410X(00)00453-9
Publication status	Published - 21 Mar 2001
Externally published	Yes

Keywords

Epidemiology
Genotype
Measles

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10.1016/S0264-410X(00)00453-9

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title = "Monitoring of measles elimination using molecular epidemiology",

abstract = "The different measles virus genotypes are confined to more or less distinct geographic regions. Molecular characterization of virus isolates has been successfully used to determine epidemiological links between cases and the geographic origin of imported viruses. In Europe, indigenous measles has been eliminated in some countries, but in others the disease is still endemic. Intra-outbreak variability can be used to differentiate between sporadic endemic cases and a 'pseudo-outbreak' of unrelated imported cases. The interruption of virus circulation by mass vaccination campaigns could be demonstrated by comparing the variability of pre-campaign viruses with post-campaign isolates. Simplified tools are being developed that could bring genotyping within reach of laboratories that do not have the possibility of sequencing.",

keywords = "Epidemiology, Genotype, Measles",

author = "Mulders, {Mick N.} and Truong, {Anh T.} and Muller, {Claude P.}",

note = "Funding Information: We would like to thank Wim Ammerlaan, Frank Hanses and Stephanie Kreis for their contribution to these studies. This work has been supported by the Minist{\`e}re de la Coop{\'e}ration, Minist{\`e}re de la Sant{\'e}, Recherche Biom{\'e}dicale a.s.b.l. and the Centre de Recherche Public — Sant{\'e}.",

year = "2001",

month = mar,

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doi = "10.1016/S0264-410X(00)00453-9",

language = "English",

volume = "19",

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journal = "Vaccine",

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TY - JOUR

T1 - Monitoring of measles elimination using molecular epidemiology

AU - Mulders, Mick N.

AU - Truong, Anh T.

AU - Muller, Claude P.

N1 - Funding Information: We would like to thank Wim Ammerlaan, Frank Hanses and Stephanie Kreis for their contribution to these studies. This work has been supported by the Ministère de la Coopération, Ministère de la Santé, Recherche Biomédicale a.s.b.l. and the Centre de Recherche Public — Santé.

PY - 2001/3/21

Y1 - 2001/3/21

N2 - The different measles virus genotypes are confined to more or less distinct geographic regions. Molecular characterization of virus isolates has been successfully used to determine epidemiological links between cases and the geographic origin of imported viruses. In Europe, indigenous measles has been eliminated in some countries, but in others the disease is still endemic. Intra-outbreak variability can be used to differentiate between sporadic endemic cases and a 'pseudo-outbreak' of unrelated imported cases. The interruption of virus circulation by mass vaccination campaigns could be demonstrated by comparing the variability of pre-campaign viruses with post-campaign isolates. Simplified tools are being developed that could bring genotyping within reach of laboratories that do not have the possibility of sequencing.

AB - The different measles virus genotypes are confined to more or less distinct geographic regions. Molecular characterization of virus isolates has been successfully used to determine epidemiological links between cases and the geographic origin of imported viruses. In Europe, indigenous measles has been eliminated in some countries, but in others the disease is still endemic. Intra-outbreak variability can be used to differentiate between sporadic endemic cases and a 'pseudo-outbreak' of unrelated imported cases. The interruption of virus circulation by mass vaccination campaigns could be demonstrated by comparing the variability of pre-campaign viruses with post-campaign isolates. Simplified tools are being developed that could bring genotyping within reach of laboratories that do not have the possibility of sequencing.

KW - Epidemiology

KW - Genotype

KW - Measles

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U2 - 10.1016/S0264-410X(00)00453-9

DO - 10.1016/S0264-410X(00)00453-9

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SN - 0264-410X

VL - 19

SP - 2245

EP - 2249

JO - Vaccine

JF - Vaccine

IS - 17-19

ER -

Monitoring of measles elimination using molecular epidemiology

Abstract

Keywords

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