Monitoring medication optimization in patients with Parkinson’s disease

Hamid Moradi*, Julius Hannink, Sabine Stallforth, Till Gladow, Stefan Ringbauer, Martin Mayr, Jürgen Winkler, Jochen Klucken, Bjoern M Eskofier

*Corresponding author for this work

Research output: Contribution to journalConference articlepeer-review


Medication optimization is a common component of the treatment strategy in patients with Parkinson’s disease. As the disease progresses, it is essential to compensate for the movement deterioration in patients. Conventionally, examining motor deterioration and prescribing medication requires the patient’s onsite presence in hospitals or practices. Home-monitoring technologies can remotely deliver essential information to physicians and help them devise a treatment decision according to the patient’s need. Additionally, they help to observe the patient’s response to these changes. In this regard, we conducted a longitudinal study to collect gait data of patients with Parkinson’s disease while they received medication changes. Using logistic regression classifier, we could detect the annotated motor deterioration during medication optimization with an accuracy of 92%. Moreover, an in-depth examination of the best features illustrated a decline in gait speed and swing phase duration in the deterioration phases due to suboptimal medication.
Original languageEnglish
Pages (from-to)69-75
Number of pages7
Publication statusE-pub ahead of print - Jul 2023
45th Annual International Conferences of the IEEE Engineering in Medicine and Biology Society, EMBC 2023
- Sidney, Australia
Duration: 24 Jul 202327 Jul 2023


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