Molecular insights into arrhythmogenic right ventricular cardiomyopathy caused by plakophilin-2 missense mutations

Keyphrases

• Arrhythmogenic Right Ventricular Cardiomyopathy 100%
• Plakophilin-2 100%
• Prevalent Diseases 10%
• Desmosome 10%
• Cardiac Pathology 10%
• Desmosomal Proteins 10%
• Expression Modeling 10%
• In Vitro Model System 10%
• Structural Modeling 10%
• Desmoplakin 10%
• In Vitro Expression 10%
• Founder mutation 10%
• Unstable Protein 10%
• Intrinsic Instability 10%
• HL-1 Cells 10%
• Dominant mutation 10%
• Inherited Cardiac Conditions 10%
• Crystallization Modeling 10%

Biochemistry, Genetics and Molecular Biology

• Missense Mutation 100%
• Plakophilin 100%
• Armadillo 30%
• Calpain 20%
• Protease 20%
• Genetics 10%
• In Vitro Study 10%
• Expression Analysis 10%
• Haploinsufficiency 10%
• Desmosome 10%
• Desmoplakin 10%