Molecular allergology and its impact in specific allergy diagnosis and therapy

Domingo Barber*, Araceli Diaz-Perales, Maria M. Escribese, Jörg Kleine-Tebbe, Paolo M. Matricardi, Markus Ollert, Alexandra F. Santos, Joaquin Sastre

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

18 Citations (Scopus)

Abstract

Progressive knowledge of allergenic structures resulted in a broad availability of allergenic molecules for diagnosis. Component-resolved diagnosis allowed a better understanding of patient sensitization patterns, facilitating allergen immunotherapy decisions. In parallel to the discovery of allergenic molecules, there was a progressive development of a regulation framework that affected both in vitro diagnostics and Allergen Immunotherapy products. With a progressive understanding of underlying mechanisms associated to Allergen immunotherapy and an increasing experience of application of molecular diagnosis in daily life, we focus in analyzing the evidences of the value provided by molecular allergology in daily clinical practice, with a focus on Allergen Immunotherapy decisions.

Original languageEnglish
Pages (from-to)3642-3658
Number of pages17
JournalAllergy: European Journal of Allergy and Clinical Immunology
Volume76
Issue number12
DOIs
Publication statusPublished - Dec 2021

Keywords

  • allergen immunotherapy
  • component-resolved diagnosis
  • food allergy
  • major allergen
  • respiratory allergy

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