Modulation of the ACOD1/itaconate pathway differentially affects atherosclerosis severity across genetic models and sexes

Lara Haase; Anouar Belkacemi; Laura Neises; Nicole Kiweler; Christine Wesely; Rosanna Huchzermeier; Maja Bozic; Arefeh Khakdan; Marta Sánchez; Arnaud Mary; Nadja Sachs; Hanna Winter; Enrico Glaab; Michael T. Heneka; Emiel P.C. van der Vorst; Michel Mittelbronn; Johannes Meiser; Jochen G. Schneider

doi:10.1172/JCI182472

Modulation of the ACOD1/itaconate pathway differentially affects atherosclerosis severity across genetic models and sexes

Lara Haase, Anouar Belkacemi, Laura Neises, Nicole Kiweler, Christine Wesely, Rosanna Huchzermeier, Maja Bozic, Arefeh Khakdan, Marta Sánchez, Arnaud Mary, Nadja Sachs, Hanna Winter, Enrico Glaab, Michael T. Heneka, Emiel P.C. van der Vorst, Michel Mittelbronn, Johannes Meiser, Jochen G. Schneider^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

Original language	English
Article number	e182472
Number of pages	4
Journal	Journal of Clinical Investigation
Volume	135
Issue number	15
DOIs	https://doi.org/10.1172/JCI182472
Publication status	Published - 12 Jun 2025

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10.1172/JCI182472Licence: CC BY

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Haase, L., Belkacemi, A., Neises, L., Kiweler, N., Wesely, C., Huchzermeier, R., Bozic, M., Khakdan, A., Sánchez, M., Mary, A., Sachs, N., Winter, H., Glaab, E., Heneka, M. T., van der Vorst, E. P. C., Mittelbronn, M., Meiser, J., & Schneider, J. G. (2025). Modulation of the ACOD1/itaconate pathway differentially affects atherosclerosis severity across genetic models and sexes. Journal of Clinical Investigation, 135(15), Article e182472. https://doi.org/10.1172/JCI182472

@article{ac8b2aac51264baeb4ea4219e3653c6d,

title = "Modulation of the ACOD1/itaconate pathway differentially affects atherosclerosis severity across genetic models and sexes",

author = "Lara Haase and Anouar Belkacemi and Laura Neises and Nicole Kiweler and Christine Wesely and Rosanna Huchzermeier and Maja Bozic and Arefeh Khakdan and Marta S{\'a}nchez and Arnaud Mary and Nadja Sachs and Hanna Winter and Enrico Glaab and Heneka, \{Michael T.\} and \{van der Vorst\}, \{Emiel P.C.\} and Michel Mittelbronn and Johannes Meiser and Schneider, \{Jochen G.\}",

note = "Funding: This work was funded by FNR-PRIDE-NEXTIMMUNE (PRIDE/11012546) from the Luxembourg National Research Fund (FNR) to LH, JS, and JM, ATTRACT-A18/BM/11809970 to JM, PEARL-P16/BM/11192868 to MM, Deutsche Forschungs- gemeinschaft (DFG-SFB894-A03) to AB, SFB-TRR219-M07 and Corona Foundation (S199/10084/2021) to EPCVDV.",

year = "2025",

month = jun,

day = "12",

doi = "10.1172/JCI182472",

language = "English",

volume = "135",

journal = "Journal of Clinical Investigation",

issn = "0021-9738",

publisher = "American Society for Clinical Investigation",

number = "15",

}

Haase, L, Belkacemi, A, Neises, L , Kiweler, N, Wesely, C, Huchzermeier, R, Bozic, M, Khakdan, A, Sánchez, M, Mary, A, Sachs, N, Winter, H, Glaab, E, Heneka, MT, van der Vorst, EPC, Mittelbronn, M, Meiser, J & Schneider, JG 2025, 'Modulation of the ACOD1/itaconate pathway differentially affects atherosclerosis severity across genetic models and sexes', Journal of Clinical Investigation, vol. 135, no. 15, e182472. https://doi.org/10.1172/JCI182472

TY - JOUR

T1 - Modulation of the ACOD1/itaconate pathway differentially affects atherosclerosis severity across genetic models and sexes

AU - Haase, Lara

AU - Belkacemi, Anouar

AU - Neises, Laura

AU - Kiweler, Nicole

AU - Wesely, Christine

AU - Huchzermeier, Rosanna

AU - Bozic, Maja

AU - Khakdan, Arefeh

AU - Sánchez, Marta

AU - Mary, Arnaud

AU - Sachs, Nadja

AU - Winter, Hanna

AU - Glaab, Enrico

AU - Heneka, Michael T.

AU - van der Vorst, Emiel P.C.

AU - Mittelbronn, Michel

AU - Meiser, Johannes

AU - Schneider, Jochen G.

N1 - Funding: This work was funded by FNR-PRIDE-NEXTIMMUNE (PRIDE/11012546) from the Luxembourg National Research Fund (FNR) to LH, JS, and JM, ATTRACT-A18/BM/11809970 to JM, PEARL-P16/BM/11192868 to MM, Deutsche Forschungs- gemeinschaft (DFG-SFB894-A03) to AB, SFB-TRR219-M07 and Corona Foundation (S199/10084/2021) to EPCVDV.

PY - 2025/6/12

Y1 - 2025/6/12

UR - https://www.scopus.com/pages/publications/105012361876

UR - https://pmc.ncbi.nlm.nih.gov/articles/PMC12324055/

U2 - 10.1172/JCI182472

DO - 10.1172/JCI182472

M3 - Article

C2 - 40504626

AN - SCOPUS:105012361876

SN - 0021-9738

VL - 135

JO - Journal of Clinical Investigation

JF - Journal of Clinical Investigation

IS - 15

M1 - e182472

ER -

Modulation of the ACOD1/itaconate pathway differentially affects atherosclerosis severity across genetic models and sexes

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