Modulation of the ACOD1/itaconate pathway differentially affects atherosclerosis severity across genetic models and sexes

Lara Haase; Anouar Belkacemi; Laura Neises; Nicole Kiweler; Christine Wesely; Rosanna Huchzermeier; Maja Bozic; Arefeh Khakdan; Marta Sánchez; Arnaud Mary; Nadja Sachs; Hanna Winter; Enrico Glaab; Michael T. Heneka; Emiel P.C. van der Vorst; Michel Mittelbronn; Johannes Meiser; Jochen G. Schneider

doi:10.1172/JCI182472

Modulation of the ACOD1/itaconate pathway differentially affects atherosclerosis severity across genetic models and sexes

Lara Haase
, Anouar Belkacemi
, Laura Neises
, Nicole Kiweler
, Christine Wesely
, Rosanna Huchzermeier
, Maja Bozic
, Arefeh Khakdan
, Marta Sánchez
, Arnaud Mary
, Nadja Sachs
, Hanna Winter
, Enrico Glaab
, Michael T. Heneka
, Emiel P.C. van der Vorst
, Michel Mittelbronn
, Johannes Meiser
, Jochen G. Schneider^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

1 Citation (Scopus)

Original language	English
Article number	e182472
Number of pages	4
Journal	Journal of Clinical Investigation
Volume	135
Issue number	15
DOIs	https://doi.org/10.1172/JCI182472
Publication status	Published - 12 Jun 2025

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10.1172/JCI182472Licence: CC BY

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Haase, L., Belkacemi, A., Neises, L., Kiweler, N., Wesely, C., Huchzermeier, R., Bozic, M., Khakdan, A., Sánchez, M., Mary, A., Sachs, N., Winter, H., Glaab, E., Heneka, M. T., van der Vorst, E. P. C., Mittelbronn, M., Meiser, J., & Schneider, J. G. (2025). Modulation of the ACOD1/itaconate pathway differentially affects atherosclerosis severity across genetic models and sexes. Journal of Clinical Investigation, 135(15), Article e182472. https://doi.org/10.1172/JCI182472

@article{ac8b2aac51264baeb4ea4219e3653c6d,

title = "Modulation of the ACOD1/itaconate pathway differentially affects atherosclerosis severity across genetic models and sexes",

author = "Lara Haase and Anouar Belkacemi and Laura Neises and Nicole Kiweler and Christine Wesely and Rosanna Huchzermeier and Maja Bozic and Arefeh Khakdan and Marta S{\'a}nchez and Arnaud Mary and Nadja Sachs and Hanna Winter and Enrico Glaab and Heneka, \{Michael T.\} and \{van der Vorst\}, \{Emiel P.C.\} and Michel Mittelbronn and Johannes Meiser and Schneider, \{Jochen G.\}",

note = "Funding: This work was funded by FNR-PRIDE-NEXTIMMUNE (PRIDE/11012546) from the Luxembourg National Research Fund (FNR) to LH, JS, and JM, ATTRACT-A18/BM/11809970 to JM, PEARL-P16/BM/11192868 to MM, Deutsche Forschungs- gemeinschaft (DFG-SFB894-A03) to AB, SFB-TRR219-M07 and Corona Foundation (S199/10084/2021) to EPCVDV.",

year = "2025",

month = jun,

day = "12",

doi = "10.1172/JCI182472",

language = "English",

volume = "135",

journal = "Journal of Clinical Investigation",

issn = "0021-9738",

publisher = "American Society for Clinical Investigation",

number = "15",

}

Haase, L, Belkacemi, A, Neises, L , Kiweler, N, Wesely, C, Huchzermeier, R, Bozic, M, Khakdan, A, Sánchez, M, Mary, A, Sachs, N, Winter, H, Glaab, E, Heneka, MT, van der Vorst, EPC, Mittelbronn, M, Meiser, J & Schneider, JG 2025, 'Modulation of the ACOD1/itaconate pathway differentially affects atherosclerosis severity across genetic models and sexes', Journal of Clinical Investigation, vol. 135, no. 15, e182472. https://doi.org/10.1172/JCI182472

TY - JOUR

T1 - Modulation of the ACOD1/itaconate pathway differentially affects atherosclerosis severity across genetic models and sexes

AU - Haase, Lara

AU - Belkacemi, Anouar

AU - Neises, Laura

AU - Kiweler, Nicole

AU - Wesely, Christine

AU - Huchzermeier, Rosanna

AU - Bozic, Maja

AU - Khakdan, Arefeh

AU - Sánchez, Marta

AU - Mary, Arnaud

AU - Sachs, Nadja

AU - Winter, Hanna

AU - Glaab, Enrico

AU - Heneka, Michael T.

AU - van der Vorst, Emiel P.C.

AU - Mittelbronn, Michel

AU - Meiser, Johannes

AU - Schneider, Jochen G.

N1 - Funding: This work was funded by FNR-PRIDE-NEXTIMMUNE (PRIDE/11012546) from the Luxembourg National Research Fund (FNR) to LH, JS, and JM, ATTRACT-A18/BM/11809970 to JM, PEARL-P16/BM/11192868 to MM, Deutsche Forschungs- gemeinschaft (DFG-SFB894-A03) to AB, SFB-TRR219-M07 and Corona Foundation (S199/10084/2021) to EPCVDV.

PY - 2025/6/12

Y1 - 2025/6/12

UR - https://www.scopus.com/pages/publications/105012361876

UR - https://pmc.ncbi.nlm.nih.gov/articles/PMC12324055/

U2 - 10.1172/JCI182472

DO - 10.1172/JCI182472

M3 - Article

C2 - 40504626

AN - SCOPUS:105012361876

SN - 0021-9738

VL - 135

JO - Journal of Clinical Investigation

JF - Journal of Clinical Investigation

IS - 15

M1 - e182472

ER -

Modulation of the ACOD1/itaconate pathway differentially affects atherosclerosis severity across genetic models and sexes

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