MiRNAs as biomarkers of myocardial infarction: A step forward towards personalized medicine?

Emeline Goretti; Daniel R. Wagner; Yvan Devaux

doi:10.1016/j.molmed.2014.10.006

MiRNAs as biomarkers of myocardial infarction: A step forward towards personalized medicine?

Emeline Goretti, Daniel R. Wagner, Yvan Devaux^*

^*Corresponding author for this work

Cardiovascular Research Unit

Research output: Contribution to journal › Review article › peer-review

89 Citations (Scopus)

Abstract

miRNAs are small noncoding RNAs known to post-transcriptionally regulate gene expression. miRNAs are expressed in the heart where they regulate multiple pathophysiological processes. The discovery of stable cardiac miRNAs in the bloodstream has also motivated the investigation of their potential as biomarkers. This review gathers the current knowledge on the use of miRNAs as novel biomarkers to improve risk stratification, diagnosis, and prognosis of patients with myocardial infarction. In the rapidly evolving era of biomarkers, the potential of miRNAs as promising tools to move personalized medicine a step forward is discussed.

Original language	English
Pages (from-to)	716-725
Number of pages	10
Journal	Trends in Molecular Medicine
Volume	20
Issue number	12
DOIs	https://doi.org/10.1016/j.molmed.2014.10.006
Publication status	Published - 1 Dec 2014

Keywords

Biomarker
MiRNAs
Myocardial infarction
Personalized medicine
Therapeutic targets

Access to Document

10.1016/j.molmed.2014.10.006

Cite this

@article{84ab6f21a0de44929de9f1042fceee4b,

title = "MiRNAs as biomarkers of myocardial infarction: A step forward towards personalized medicine?",

abstract = "miRNAs are small noncoding RNAs known to post-transcriptionally regulate gene expression. miRNAs are expressed in the heart where they regulate multiple pathophysiological processes. The discovery of stable cardiac miRNAs in the bloodstream has also motivated the investigation of their potential as biomarkers. This review gathers the current knowledge on the use of miRNAs as novel biomarkers to improve risk stratification, diagnosis, and prognosis of patients with myocardial infarction. In the rapidly evolving era of biomarkers, the potential of miRNAs as promising tools to move personalized medicine a step forward is discussed.",

keywords = "Biomarker, MiRNAs, Myocardial infarction, Personalized medicine, Therapeutic targets",

author = "Emeline Goretti and Wagner, {Daniel R.} and Yvan Devaux",

note = "Publisher Copyright: {\textcopyright} 2014 Elsevier Ltd.",

year = "2014",

month = dec,

day = "1",

doi = "10.1016/j.molmed.2014.10.006",

language = "English",

volume = "20",

pages = "716--725",

journal = "Trends in Molecular Medicine",

issn = "1471-4914",

publisher = "Elsevier Ltd.",

number = "12",

}

TY - JOUR

T1 - MiRNAs as biomarkers of myocardial infarction

T2 - A step forward towards personalized medicine?

AU - Goretti, Emeline

AU - Wagner, Daniel R.

AU - Devaux, Yvan

PY - 2014/12/1

Y1 - 2014/12/1

N2 - miRNAs are small noncoding RNAs known to post-transcriptionally regulate gene expression. miRNAs are expressed in the heart where they regulate multiple pathophysiological processes. The discovery of stable cardiac miRNAs in the bloodstream has also motivated the investigation of their potential as biomarkers. This review gathers the current knowledge on the use of miRNAs as novel biomarkers to improve risk stratification, diagnosis, and prognosis of patients with myocardial infarction. In the rapidly evolving era of biomarkers, the potential of miRNAs as promising tools to move personalized medicine a step forward is discussed.

AB - miRNAs are small noncoding RNAs known to post-transcriptionally regulate gene expression. miRNAs are expressed in the heart where they regulate multiple pathophysiological processes. The discovery of stable cardiac miRNAs in the bloodstream has also motivated the investigation of their potential as biomarkers. This review gathers the current knowledge on the use of miRNAs as novel biomarkers to improve risk stratification, diagnosis, and prognosis of patients with myocardial infarction. In the rapidly evolving era of biomarkers, the potential of miRNAs as promising tools to move personalized medicine a step forward is discussed.

KW - Biomarker

KW - MiRNAs

KW - Myocardial infarction

KW - Personalized medicine

KW - Therapeutic targets

UR - http://www.scopus.com/inward/record.url?scp=84915754365&partnerID=8YFLogxK

U2 - 10.1016/j.molmed.2014.10.006

DO - 10.1016/j.molmed.2014.10.006

M3 - Review article

C2 - 25457620

AN - SCOPUS:84915754365

SN - 1471-4914

VL - 20

SP - 716

EP - 725

JO - Trends in Molecular Medicine

JF - Trends in Molecular Medicine

IS - 12

ER -

MiRNAs as biomarkers of myocardial infarction: A step forward towards personalized medicine?

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this