MiRNAs as biomarkers of myocardial infarction: A step forward towards personalized medicine?

Emeline Goretti, Daniel R. Wagner, Yvan Devaux*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

88 Citations (Scopus)

Abstract

miRNAs are small noncoding RNAs known to post-transcriptionally regulate gene expression. miRNAs are expressed in the heart where they regulate multiple pathophysiological processes. The discovery of stable cardiac miRNAs in the bloodstream has also motivated the investigation of their potential as biomarkers. This review gathers the current knowledge on the use of miRNAs as novel biomarkers to improve risk stratification, diagnosis, and prognosis of patients with myocardial infarction. In the rapidly evolving era of biomarkers, the potential of miRNAs as promising tools to move personalized medicine a step forward is discussed.

Original languageEnglish
Pages (from-to)716-725
Number of pages10
JournalTrends in Molecular Medicine
Volume20
Issue number12
DOIs
Publication statusPublished - 1 Dec 2014

Keywords

  • Biomarker
  • MiRNAs
  • Myocardial infarction
  • Personalized medicine
  • Therapeutic targets

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