miRNA signatures in childhood sarcomas and their clinical implications

G. M. Viera, K. B. Salomao, G. R. de Sousa, M. Baroni, L. E.A. Delsin, J. A. Pezuk, M. S. Brassesco*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

15 Citations (Scopus)

Abstract

Progresses in multimodal treatments have significantly improved the outcomes for childhood cancer. Nonetheless, for about one-third of patients with Ewing sarcoma, rhabdomyosarcoma, or osteosarcoma steady remission has remained intangible. Thus, new biomarkers to improve early diagnosis and the development of precision-targeted medicine remain imperative. Over the last decade, remarkable progress has been made in the basic understanding of miRNAs function and in interpreting the contribution of their dysregulation to cancer development and progression. On this basis, this review focuses on what has been learned about the pivotal roles of miRNAs in the regulation of key genes implicated in childhood sarcomas.

Original languageEnglish
Pages (from-to)1583-1623
Number of pages41
JournalClinical and Translational Oncology
Volume21
Issue number12
DOIs
Publication statusPublished - 1 Dec 2019
Externally publishedYes

Keywords

  • Cancer
  • Children
  • miRNA
  • Review
  • Sarcoma

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