Milk-blood transfer of 14C-tagged polycyclic aromatic hydrocarbons (PAHs) in pigs

Claire Laurent; Cyril Feidt; Eric Lichtfouse; Nathalie Grova; François Laurent; Guido Rychen

doi:10.1021/jf0014011

Milk-blood transfer of ¹⁴C-tagged polycyclic aromatic hydrocarbons (PAHs) in pigs

Claire Laurent, Cyril Feidt, Eric Lichtfouse, Nathalie Grova, François Laurent, Guido Rychen^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

26 Citations (Scopus)

Abstract

Polycyclic aromatic hydrocarbons (PAHs) are lipophilic organic pollutants occurring widely in the terrestrial environment. To study the transfer of PAHs in the food chain, pigs have been fed with milk spiked either with [¹⁴C]phenanthrene or with [¹⁴C]benzo[α]pyrene. The analysis of blood radioactivity showed that both PAHs were absorbed with a maximum concentration at 5-6 h after milk ingestion, similar to fat metabolism. The blood radioactivity then decreased to reach background levels 24 h after milk ingestion. Furthermore, the blood radioactivity was higher for phenanthrene (even if the injected load was the lowest) than for benzo[α]pyrene, in agreement with their solubility difference. These findings suggest that milk fat and PAHs were absorbed during the same time period.

Original language	English
Pages (from-to)	2493-2496
Number of pages	4
Journal	Journal of Agricultural and Food Chemistry
Volume	49
Issue number	5
DOIs	https://doi.org/10.1021/jf0014011
Publication status	Published - 2001
Externally published	Yes

Keywords

Animal
Bioavailability
Blood
Milk
PAHs
Pig
Toxicity
Transfer

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10.1021/jf0014011

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title = "Milk-blood transfer of 14C-tagged polycyclic aromatic hydrocarbons (PAHs) in pigs",

abstract = "Polycyclic aromatic hydrocarbons (PAHs) are lipophilic organic pollutants occurring widely in the terrestrial environment. To study the transfer of PAHs in the food chain, pigs have been fed with milk spiked either with [14C]phenanthrene or with [14C]benzo[α]pyrene. The analysis of blood radioactivity showed that both PAHs were absorbed with a maximum concentration at 5-6 h after milk ingestion, similar to fat metabolism. The blood radioactivity then decreased to reach background levels 24 h after milk ingestion. Furthermore, the blood radioactivity was higher for phenanthrene (even if the injected load was the lowest) than for benzo[α]pyrene, in agreement with their solubility difference. These findings suggest that milk fat and PAHs were absorbed during the same time period.",

keywords = "Animal, Bioavailability, Blood, Milk, PAHs, Pig, Toxicity, Transfer",

author = "Claire Laurent and Cyril Feidt and Eric Lichtfouse and Nathalie Grova and Fran{\c c}ois Laurent and Guido Rychen",

year = "2001",

doi = "10.1021/jf0014011",

language = "English",

volume = "49",

pages = "2493--2496",

journal = "Journal of Agricultural and Food Chemistry",

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publisher = "American Chemical Society",

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TY - JOUR

T1 - Milk-blood transfer of 14C-tagged polycyclic aromatic hydrocarbons (PAHs) in pigs

AU - Laurent, Claire

AU - Feidt, Cyril

AU - Lichtfouse, Eric

AU - Grova, Nathalie

AU - Laurent, François

AU - Rychen, Guido

PY - 2001

Y1 - 2001

N2 - Polycyclic aromatic hydrocarbons (PAHs) are lipophilic organic pollutants occurring widely in the terrestrial environment. To study the transfer of PAHs in the food chain, pigs have been fed with milk spiked either with [14C]phenanthrene or with [14C]benzo[α]pyrene. The analysis of blood radioactivity showed that both PAHs were absorbed with a maximum concentration at 5-6 h after milk ingestion, similar to fat metabolism. The blood radioactivity then decreased to reach background levels 24 h after milk ingestion. Furthermore, the blood radioactivity was higher for phenanthrene (even if the injected load was the lowest) than for benzo[α]pyrene, in agreement with their solubility difference. These findings suggest that milk fat and PAHs were absorbed during the same time period.

AB - Polycyclic aromatic hydrocarbons (PAHs) are lipophilic organic pollutants occurring widely in the terrestrial environment. To study the transfer of PAHs in the food chain, pigs have been fed with milk spiked either with [14C]phenanthrene or with [14C]benzo[α]pyrene. The analysis of blood radioactivity showed that both PAHs were absorbed with a maximum concentration at 5-6 h after milk ingestion, similar to fat metabolism. The blood radioactivity then decreased to reach background levels 24 h after milk ingestion. Furthermore, the blood radioactivity was higher for phenanthrene (even if the injected load was the lowest) than for benzo[α]pyrene, in agreement with their solubility difference. These findings suggest that milk fat and PAHs were absorbed during the same time period.

KW - Animal

KW - Bioavailability

KW - Blood

KW - Milk

KW - PAHs

KW - Pig

KW - Toxicity

KW - Transfer

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U2 - 10.1021/jf0014011

DO - 10.1021/jf0014011

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SN - 0021-8561

VL - 49

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EP - 2496

JO - Journal of Agricultural and Food Chemistry

JF - Journal of Agricultural and Food Chemistry

IS - 5

ER -

Milk-blood transfer of ¹⁴C-tagged polycyclic aromatic hydrocarbons (PAHs) in pigs

Abstract

Keywords

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