TY - JOUR
T1 - Microtubules and viral infection
AU - da Silva, Eveline Santos
AU - Naghavi, Mojgan H.
N1 - Funding Information:
We apologize to our many colleagues whose work was not cited due to the focus and space limitations of this review. This work was funded by the grant (R01AI150559) from the National Institutes of Health to M.H.N.
Publisher Copyright:
© 2023 Elsevier Inc.
PY - 2023/4/3
Y1 - 2023/4/3
N2 - Microtubules (MTs) form rapidly adaptable, complex intracellular networks of filaments that not only provide structural support, but also form the tracks along which motors traffic macromolecular cargos to specific sub-cellular sites. These dynamic arrays play a central role in regulating various cellular processes including cell shape and motility as well as cell division and polarization. Given their complex organization and functional importance, MT arrays are carefully controlled by many highly specialized proteins that regulate the nucleation of MT filaments at distinct sites, their dynamic growth and stability, and their engagement with other subcellular structures and cargoes destined for transport. This review focuses on recent advances in our understanding of how MTs and their regulatory proteins function, including their active targeting and exploitation, during infection by viruses that utilize a wide variety of replication strategies that occur within different cellular sub-compartments or regions of the cell.
AB - Microtubules (MTs) form rapidly adaptable, complex intracellular networks of filaments that not only provide structural support, but also form the tracks along which motors traffic macromolecular cargos to specific sub-cellular sites. These dynamic arrays play a central role in regulating various cellular processes including cell shape and motility as well as cell division and polarization. Given their complex organization and functional importance, MT arrays are carefully controlled by many highly specialized proteins that regulate the nucleation of MT filaments at distinct sites, their dynamic growth and stability, and their engagement with other subcellular structures and cargoes destined for transport. This review focuses on recent advances in our understanding of how MTs and their regulatory proteins function, including their active targeting and exploitation, during infection by viruses that utilize a wide variety of replication strategies that occur within different cellular sub-compartments or regions of the cell.
KW - Cytoskeleton
KW - Microtubules
KW - Motors
KW - Trafficking
KW - Virus
UR - http://www.scopus.com/inward/record.url?scp=85151533593&partnerID=8YFLogxK
UR - https://pubmed.ncbi.nlm.nih.gov/37173066
U2 - 10.1016/bs.aivir.2023.02.003
DO - 10.1016/bs.aivir.2023.02.003
M3 - Article
C2 - https://pubmed.ncbi.nlm.nih.gov/37173066/
AN - SCOPUS:85151533593
SN - 0065-3527
VL - 115
SP - 87
EP - 134
JO - Advances in Virus Research
JF - Advances in Virus Research
ER -