MicroRNAs in cancer management and their modulation by dietary agents

Tommy Karius; Michael Schnekenburger; Mario Dicato; Marc Diederich

doi:10.1016/j.bcp.2012.02.004

MicroRNAs in cancer management and their modulation by dietary agents

Tommy Karius, Michael Schnekenburger, Mario Dicato, Marc Diederich^*

^*Corresponding author for this work

Research output: Contribution to journal › Comment/debate

62 Citations (Scopus)

Abstract

MicroRNAs (miRNAs) represent a class of small (21-23 nucleotides) non-coding RNAs that emerged as key post-transcriptional gene regulators, implicated in numerous physiological and pathological processes. Currently, a main focus of miRNA research is related to the roles of miRNAs in cancer development. The biogenesis and modes of action of miRNAs have not been completely elucidated; however, miRNA-mediated translational repression is involved in the regulation of almost every cellular process. Thus, pathological alterations in miRNA expression signatures are commonly associated with disease development. This review specifically focuses on miRNAs in cancer, with an emphasis on their use as potential biomarkers for cancer diagnosis and prognosis. Then, we discuss the potential use of synthetic antisense or miRNA mimetic oligonucleotides and dietary agents to modulate miRNA expression for chemotherapy and chemoprevention of cancer, respectively.

Original language	English
Pages (from-to)	1591-1601
Number of pages	11
Journal	Biochemical Pharmacology
Volume	83
Issue number	12
DOIs	https://doi.org/10.1016/j.bcp.2012.02.004
Publication status	Published - 15 Jun 2012
Externally published	Yes

Keywords

Biomarker
Cancer
Chemoprevention
Chemotherapy
Dietary agents
microRNA
miRNA inhibitors
miRNA mimics

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10.1016/j.bcp.2012.02.004

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title = "MicroRNAs in cancer management and their modulation by dietary agents",

abstract = "MicroRNAs (miRNAs) represent a class of small (21-23 nucleotides) non-coding RNAs that emerged as key post-transcriptional gene regulators, implicated in numerous physiological and pathological processes. Currently, a main focus of miRNA research is related to the roles of miRNAs in cancer development. The biogenesis and modes of action of miRNAs have not been completely elucidated; however, miRNA-mediated translational repression is involved in the regulation of almost every cellular process. Thus, pathological alterations in miRNA expression signatures are commonly associated with disease development. This review specifically focuses on miRNAs in cancer, with an emphasis on their use as potential biomarkers for cancer diagnosis and prognosis. Then, we discuss the potential use of synthetic antisense or miRNA mimetic oligonucleotides and dietary agents to modulate miRNA expression for chemotherapy and chemoprevention of cancer, respectively.",

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TY - JOUR

T1 - MicroRNAs in cancer management and their modulation by dietary agents

AU - Karius, Tommy

AU - Schnekenburger, Michael

AU - Dicato, Mario

AU - Diederich, Marc

PY - 2012/6/15

Y1 - 2012/6/15

N2 - MicroRNAs (miRNAs) represent a class of small (21-23 nucleotides) non-coding RNAs that emerged as key post-transcriptional gene regulators, implicated in numerous physiological and pathological processes. Currently, a main focus of miRNA research is related to the roles of miRNAs in cancer development. The biogenesis and modes of action of miRNAs have not been completely elucidated; however, miRNA-mediated translational repression is involved in the regulation of almost every cellular process. Thus, pathological alterations in miRNA expression signatures are commonly associated with disease development. This review specifically focuses on miRNAs in cancer, with an emphasis on their use as potential biomarkers for cancer diagnosis and prognosis. Then, we discuss the potential use of synthetic antisense or miRNA mimetic oligonucleotides and dietary agents to modulate miRNA expression for chemotherapy and chemoprevention of cancer, respectively.

AB - MicroRNAs (miRNAs) represent a class of small (21-23 nucleotides) non-coding RNAs that emerged as key post-transcriptional gene regulators, implicated in numerous physiological and pathological processes. Currently, a main focus of miRNA research is related to the roles of miRNAs in cancer development. The biogenesis and modes of action of miRNAs have not been completely elucidated; however, miRNA-mediated translational repression is involved in the regulation of almost every cellular process. Thus, pathological alterations in miRNA expression signatures are commonly associated with disease development. This review specifically focuses on miRNAs in cancer, with an emphasis on their use as potential biomarkers for cancer diagnosis and prognosis. Then, we discuss the potential use of synthetic antisense or miRNA mimetic oligonucleotides and dietary agents to modulate miRNA expression for chemotherapy and chemoprevention of cancer, respectively.

KW - Biomarker

KW - Cancer

KW - Chemoprevention

KW - Chemotherapy

KW - Dietary agents

KW - microRNA

KW - miRNA inhibitors

KW - miRNA mimics

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DO - 10.1016/j.bcp.2012.02.004

M3 - Comment/debate

AN - SCOPUS:84860127568

SN - 0006-2952

VL - 83

SP - 1591

EP - 1601

JO - Biochemical Pharmacology

JF - Biochemical Pharmacology

IS - 12

ER -

MicroRNAs in cancer management and their modulation by dietary agents

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Keywords

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