TY - JOUR
T1 - Micronutrients and markers of oxidative stress and inflammation related to cardiometabolic health
T2 - Results from the ehes-lux study
AU - Ruiz-Castell, Maria
AU - Coroller, Gwenaëlle Le
AU - Landrier, Jean Francois
AU - Kerkour, Djedgiga
AU - Weber, Bernard
AU - Fagherazzi, Guy
AU - Appenzeller, Brice M.R.
AU - Vaillant, Michel
AU - Bohn, Torsten
N1 - Funding Information:
Acknowledgments: We are grateful to the population of Luxembourg and to all of the EHES-LUX team who have contributed to this study. We would like to thank Couffignal, S., Kuemmerle, A., Dincau, M., Mormont, D., Barre, J., Chioti, A., Delagardelle, C., Michel, G., Schlesser, M., Schmit, J.C., Gantenbein, M., Lieunard, C., Columeau, A., Kiemen, M., Weis, J., Ambroset, G., Billy, A., Larcelet, M., Marcic, D., Gauthier, C., Leners, B., Viau-Courville, M., Couturier, C. and Astier, J. for their valuable contributions. This research was funded by the National Research Fund of Luxembourg ([C17/BM/11653863/iMPACT.lu to MRC)], the Directorate and Ministry of Health, and the Ministry of Higher Education and Research (MESR).
Funding Information:
Funding: This research was funded by the National Research Fund of Luxembourg (C17/BM/11653863/ iMPACT.lu to MRC), the Directorate and Ministry of Health, and the Ministry of Higher Education and Research (MESR).
Publisher Copyright:
© 2020 by the authors. Li-censee MDPI, Basel, Switzerland.
PY - 2021/1/1
Y1 - 2021/1/1
N2 - Metabolic syndrome (MetS) characteristics include chronic inflammation and elevated oxidative stress. This study assessed associations between circulating concentrations of micronutri-ents/phytochemicals and inflammatory/oxidative stress markers with MetS and MetS components. Adults (N = 606) from the European Health Examination Survey in Luxembourg (2013–2015) were randomly selected. We performed a multivariable logistic regression model using the least absolute shrinkage and selection operator to identify MetS-associated variables. Participants with MetS had higher concentrations of C-reactive protein (CRP), 8-iso-prostaglandin F2α, leptin, insulin, and vitamins E/A, but lower concentrations of adiponectin, beta-carotene, and oxidized low-density lipoprotein. A one-unit increase in log-CRP was associated with 51% greater odds of MetS (OR = 1.51 (95% CI: 1.16, 1.98)). Adults with a one-unit increase in log-leptin were 3.1 times more likely to have MetS (3.10 (2.10, 4.72)). Women with a one-unit increase in vitamin A were associated with 3% increased odds of MetS (1.03 (1.01, 1.05)), while those with a one-unit increase in log-adiponectin were associated with 82% decreased odds (0.18 (0.07, 0.46)). Chronic inflammation best characterized adults with MetS, as CRP, adiponectin, and leptin were selected as the main MetS determinants. Micronutrients did not seem to affect MetS, except for vitamin A in women.
AB - Metabolic syndrome (MetS) characteristics include chronic inflammation and elevated oxidative stress. This study assessed associations between circulating concentrations of micronutri-ents/phytochemicals and inflammatory/oxidative stress markers with MetS and MetS components. Adults (N = 606) from the European Health Examination Survey in Luxembourg (2013–2015) were randomly selected. We performed a multivariable logistic regression model using the least absolute shrinkage and selection operator to identify MetS-associated variables. Participants with MetS had higher concentrations of C-reactive protein (CRP), 8-iso-prostaglandin F2α, leptin, insulin, and vitamins E/A, but lower concentrations of adiponectin, beta-carotene, and oxidized low-density lipoprotein. A one-unit increase in log-CRP was associated with 51% greater odds of MetS (OR = 1.51 (95% CI: 1.16, 1.98)). Adults with a one-unit increase in log-leptin were 3.1 times more likely to have MetS (3.10 (2.10, 4.72)). Women with a one-unit increase in vitamin A were associated with 3% increased odds of MetS (1.03 (1.01, 1.05)), while those with a one-unit increase in log-adiponectin were associated with 82% decreased odds (0.18 (0.07, 0.46)). Chronic inflammation best characterized adults with MetS, as CRP, adiponectin, and leptin were selected as the main MetS determinants. Micronutrients did not seem to affect MetS, except for vitamin A in women.
KW - Adipokines
KW - Antioxidants
KW - Cardio metabolic health
KW - Population based study
KW - Secondary plant compounds
UR - http://www.scopus.com/inward/record.url?scp=85098639645&partnerID=8YFLogxK
UR - https://pubmed.ncbi.nlm.nih.gov/33374992
U2 - 10.3390/nu13010005
DO - 10.3390/nu13010005
M3 - Article
C2 - 33374992
AN - SCOPUS:85098639645
SN - 2072-6643
VL - 13
SP - 1
EP - 13
JO - Nutrients
JF - Nutrients
IS - 1
M1 - 5
ER -