Microfluidic multi-tissue platform for systemic embryotoxicity testing along the maternal-placental-embryonic axis

Julia A. Boos*, Patrick M. Misun, Giulia Brunoldi, Lea A. Furer, Leonie Aengenheister, Mario Modena, Nassim Rousset, Tina Buerki-Thurnherr, Andreas Hierlemann

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

A microfluidic co-culture platform for systemic embryotoxicity testing along the maternal-placental-embryonic axis is presented. We advanced the hanging-drop network (HDN) technology by combining a 2D placental barrier with 3D embryoid bodies (EBs) in immediate vicinity in a single microfluidic network. In contrast to previous approaches, the newly developed platform does not only allow for studying effects of direct toxicity on the individual tissue models but also enables the investigation of indirect embryotoxicity effects, mediated by factors secreted by the placental tissue.

Original languageEnglish
Title of host publicationMicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages1695-1696
Number of pages2
ISBN (Electronic)9781733419031
Publication statusPublished - 2021
Externally publishedYes
Event25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021 - Palm Springs, Virtual, United States
Duration: 10 Oct 202114 Oct 2021

Publication series

NameMicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Conference

Conference25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021
Country/TerritoryUnited States
CityPalm Springs, Virtual
Period10/10/2114/10/21

Keywords

  • 3D microtissues
  • embryoid bodies
  • embryotoxicity testing
  • hanging drops
  • microfluidics
  • placenta

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