TY - GEN
T1 - Microfluidic multi-tissue platform for systemic embryotoxicity testing along the maternal-placental-embryonic axis
AU - Boos, Julia A.
AU - Misun, Patrick M.
AU - Brunoldi, Giulia
AU - Furer, Lea A.
AU - Aengenheister, Leonie
AU - Modena, Mario
AU - Rousset, Nassim
AU - Buerki-Thurnherr, Tina
AU - Hierlemann, Andreas
N1 - Funding Information:
This work was financially supported by the ETH Research Grant ETH-11 61-1. T. Buerki-Thurnherr received funding from the Swiss National Science Foundation (grant no. 31003A_179337).
Publisher Copyright:
© 2021 MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.
PY - 2021
Y1 - 2021
N2 - A microfluidic co-culture platform for systemic embryotoxicity testing along the maternal-placental-embryonic axis is presented. We advanced the hanging-drop network (HDN) technology by combining a 2D placental barrier with 3D embryoid bodies (EBs) in immediate vicinity in a single microfluidic network. In contrast to previous approaches, the newly developed platform does not only allow for studying effects of direct toxicity on the individual tissue models but also enables the investigation of indirect embryotoxicity effects, mediated by factors secreted by the placental tissue.
AB - A microfluidic co-culture platform for systemic embryotoxicity testing along the maternal-placental-embryonic axis is presented. We advanced the hanging-drop network (HDN) technology by combining a 2D placental barrier with 3D embryoid bodies (EBs) in immediate vicinity in a single microfluidic network. In contrast to previous approaches, the newly developed platform does not only allow for studying effects of direct toxicity on the individual tissue models but also enables the investigation of indirect embryotoxicity effects, mediated by factors secreted by the placental tissue.
KW - 3D microtissues
KW - embryoid bodies
KW - embryotoxicity testing
KW - hanging drops
KW - microfluidics
KW - placenta
UR - http://www.scopus.com/inward/record.url?scp=85136942297&partnerID=8YFLogxK
UR - https://www.research-collection.ethz.ch/handle/20.500.11850/528726
M3 - Conference contribution
AN - SCOPUS:85136942297
T3 - MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences
SP - 1695
EP - 1696
BT - MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PB - Chemical and Biological Microsystems Society
T2 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021
Y2 - 10 October 2021 through 14 October 2021
ER -