Mesenchymal stem cell signaling in cancer progression

Anja Torsvik*, Rolf Bjerkvig

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    92 Citations (Scopus)

    Abstract

    Mesenchymal (multipotent) stem/stromal cells (MSCs) may affect cancer progression through a number of secreted factors triggering activation of various cell signaling pathways. Depending on receptor status, phosphatase and tensin homolog (PTEN) status, or Wnt activation in the cancer cells, the signals may either result in increased growth and metastasis or lead to inhibition of growth with increased cell death. Thus, MSCs can play a dual role in cancer progression depending on the cellular context wherein they reside. The phosphatidylinositol-3-kinase (PI3K)/Akt signaling pathway has a central role in regulating tumor growth, and several MSC secreted factors stimulate activation of this pathway. A comprehensive understanding of the signals regulating MSC-tumor cross-talk is highly important for the development of MSCs as potential therapeutic vehicles. Thus, the presented review focuses on factors released by MSCs and on the dual role they may have on various stages of tumorigenesis.

    Original languageEnglish
    Pages (from-to)180-188
    Number of pages9
    JournalCancer Treatment Reviews
    Volume39
    Issue number2
    DOIs
    Publication statusPublished - Apr 2013

    Keywords

    • Cancer
    • Mesenchymal stem cells
    • PI3K/Akt pathway
    • Tumor microenvironment
    • Tumor stroma

    Fingerprint

    Dive into the research topics of 'Mesenchymal stem cell signaling in cancer progression'. Together they form a unique fingerprint.

    Cite this