MERTK-Dependent Ensheathment of Photoreceptor Outer Segments by Human Pluripotent Stem Cell-Derived Retinal Pigment Epithelium

Seba Almedawar*, Katerina Vafia, Sven Schreiter, Katrin Neumann, Shahryar Khattak, Thomas Kurth, Marius Ader, Mike O. Karl, Stephen H. Tsang, Elly M. Tanaka

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Abstract

Using ultrastructural scanning electron microscopy (SEM)-based analysis, Almedawar et al. show that MERTK ligands, GAS6 and PROS1, upregulate photoreceptor outer segments (POS) ensheathment in human embryonic stem cell-derived retinal pigment epithelial cells. The authors also demonstrate that MERTK is essential for POS ensheathment and fragmentation before internalization, and suggest that ensheathment defects contribute to the pathology of retinitis pigmentosa type 38.

Original languageEnglish
Pages (from-to)374-389
Number of pages16
JournalStem Cell Reports
Volume14
Issue number3
DOIs
Publication statusPublished - 10 Mar 2020
Externally publishedYes

Keywords

  • GAS6
  • MERTK
  • MFGE8
  • PROS1
  • ensheathment
  • human embryonic stem cells
  • human pluripotent stem cells
  • phagocytosis
  • photoreceptor outer segments
  • retinal pigment epithelium

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