TY - JOUR
T1 - Mentally tiring work and type 2 diabetes in women
T2 - A 22-year follow-up study
AU - Fagherazzi, Guy
AU - Gusto, Gaelle
AU - Fatouhi, Douae El
AU - Mancini, Francesca Romana
AU - Balkau, Beverley
AU - Boutron-Ruault, Marie Christine
AU - Bonnet, Fabrice
N1 - Funding Information:
The E3N cohort is being carried out with the financial support of the ‘Mutuelle Générale de l’Education Nationale’, European Community, French League against Cancer, Gustave Roussy, and French Institute of Health and Medical Research. The present study was also supported by the French Research Agency (Agence Nationale de la Recherche) via an ‘ 阀nvestissement d’Avenir’ grant (investment for the future grant, ANR-10-COHO-0006) that supports the E4N study and 阀✀EX Paris Saclay (Nutriperso project). The funders had no role in the design and conduct of the study, collection, management, analysis and interpretation of the data or preparation, review, approval of this manuscript.
Publisher Copyright:
© 2019 European Society of Endocrinology.
PY - 2019/4/1
Y1 - 2019/4/1
N2 - Hypothesis: Previous work suggested no or inconsistent associations between components of work-related stress and type 2 diabetes risk, but suggested sex-specific differences should be further investigated, as women potentially had higher risks. Methods: We analyzed data from 73 517 women, mostly teachers, from the E3N cohort study followed for 22 years (1992–2014), to study the association between mentally tiring work, used as a proxy of job demands, and type 2 diabetes risk. Univariate and multivariable Cox regression models were used to estimate hazard ratios and 95% confidence intervals. Results: A total of 4187 incident cases of type 2 diabetes cases were observed. There was a higher type 2 diabetes risk for women with a ‘Very mentally tiring work’ when compared to women with ‘Little or not mentally tiring work’ (HR = 1.21 (1.09–1.35)). This association was independent of unhealthy lifestyle and traditional metabolic factors. An interaction between mentally tiring work and BMI was detected (P < 0.0001), with a stronger association being observed in non-overweight women, HR = 1.26 (1.08–1.47) vs HR = 1.14 (0.98, 1.32), in overweight women. Conclusions: We observed an increased risk of type 2 diabetes associated with mentally tiring work, used as a proxy of job demands. These observational results suggest the importance of taking into consideration the potential long-term metabolic impact of work-related stress for women working in a demanding environment. Increased support for such women should be investigated in intervention studies.
AB - Hypothesis: Previous work suggested no or inconsistent associations between components of work-related stress and type 2 diabetes risk, but suggested sex-specific differences should be further investigated, as women potentially had higher risks. Methods: We analyzed data from 73 517 women, mostly teachers, from the E3N cohort study followed for 22 years (1992–2014), to study the association between mentally tiring work, used as a proxy of job demands, and type 2 diabetes risk. Univariate and multivariable Cox regression models were used to estimate hazard ratios and 95% confidence intervals. Results: A total of 4187 incident cases of type 2 diabetes cases were observed. There was a higher type 2 diabetes risk for women with a ‘Very mentally tiring work’ when compared to women with ‘Little or not mentally tiring work’ (HR = 1.21 (1.09–1.35)). This association was independent of unhealthy lifestyle and traditional metabolic factors. An interaction between mentally tiring work and BMI was detected (P < 0.0001), with a stronger association being observed in non-overweight women, HR = 1.26 (1.08–1.47) vs HR = 1.14 (0.98, 1.32), in overweight women. Conclusions: We observed an increased risk of type 2 diabetes associated with mentally tiring work, used as a proxy of job demands. These observational results suggest the importance of taking into consideration the potential long-term metabolic impact of work-related stress for women working in a demanding environment. Increased support for such women should be investigated in intervention studies.
UR - http://www.scopus.com/inward/record.url?scp=85062618523&partnerID=8YFLogxK
U2 - 10.1530/EJE-18-0804
DO - 10.1530/EJE-18-0804
M3 - Article
C2 - 30840582
AN - SCOPUS:85062618523
SN - 0804-4643
VL - 180
SP - 257
EP - 263
JO - European Journal of Endocrinology
JF - European Journal of Endocrinology
IS - 4
ER -