Measles elimination: Old and new challenges?

Claude P. Muller*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)


Life attenuated measles vaccines have dramatically reduced measles morbidity and mortality world-wide. Despite high vaccination coverage, measles outbreaks continue to occur both in developed and developing countries. While secondary vaccine failure may be responsible for disease in some seroconverted individuals, evidence suggests that many more vaccinees who are protected against disease may not be fully protected against virus infection. In low-income developing countries protection by maternal antibodies seems to erode faster than previously estimated especially in infants who were born to vaccinated mothers. Problems of infectivity and susceptibility of vaccinees will be compounded in case wild-type viruses become less sensitive to vaccine induced immunity. These observations suggest that elimination may be more easily achieved as long as large proportions of populations are protected by wild-type virus-induced immunity.

Original languageEnglish
Pages (from-to)2258-2261
Number of pages4
Issue number17-19
Publication statusPublished - 21 Mar 2001
Externally publishedYes


  • Measles virus
  • Secondary immune response
  • Vaccination


Dive into the research topics of 'Measles elimination: Old and new challenges?'. Together they form a unique fingerprint.

Cite this