TY - JOUR
T1 - Marker allergens in Hymenoptera venom allergy — Characteristics and potential use in precision medicine
AU - Blank, Simon
AU - Bilò, Maria Beatrice
AU - Grosch, Johannes
AU - Schmidt-Weber, Carsten B.
AU - Ollert, Markus
AU - Jakob, Thilo
N1 - Not indexed in PubMed
Funding Information:
S. Blank reports nonfinancial support from ALK-Abelló, grants and personal fees from Bencard Allergie GmbH, personal fees from Teomed AG, grants from Leti Pharma, grants and personal fees from Thermo Fisher Scientific, grants from Allergy Therapeutics, outside the submitted work. In addition, S. Blank has a patent “Cloning of honey bee allergen C” licensed to Thermo Fisher Scientific. M.B. Bilò has received speaker’s honorarium and consultancy fees from ALK-Abelló, outside the submitted work. C.B. Schmidt-Weber reports grants and personal fees from Bencard, grants from Leti Pharma, grants and personal fees from Allergopharma, grants and personal fees from PLS Design, outside the submitted work. In addition, C.B. Schmidt-Weber has a patent on diagnostic success prediction in AIT pending. M. Ollert reports personal fees from Thermo Fisher Scientific, Siemens Healthcare Diagnostics, Hitachi Chemical Diagnostics and Hycor, outside the submitted work; and is Scientific cofounder of the academic biotech spin-offs PLS-Design GmbH, Hamburg, Germany and Tolerogenics SARL; Luxembourg. T. Jakob reports grants, personal fees and nonfinancial support from ALK-Abelló, personal fees and nonfinancial support from Bencard/Allergy Therapeutics, grants, personal fees and nonfinancial support from Novartis, personal fees and nonfinancial support from Thermo Fisher Scientific, personal fees from Celgene, personal fees from Allergopharma, outside the submitted work. J. Grosch declares that he has no competing interests.
Funding Information:
This work was supported by the Helmholtz Association, Future Topic “Immunology and Inflammation” (ZT-0027) to S. Blank and C.B. Schmidt-Weber and in part by a grant (NR66-0004) of the von-Behring-Röntgen-Stiftung, Marburg and UKGM Research Funding (7/2017GI), Giessen, to T. Jakob. Open access funding was provided by Project DEAL.
Publisher Copyright:
© 2020, The Author(s).
PY - 2021/2
Y1 - 2021/2
N2 - Background: A comprehensive diagnostic work-up is essential to ensure adequate patient management for the potentially life-threatening condition of Hymenoptera venom allergy (HVA). This includes an unambiguous identification of the allergy-relevant venom as prerequisite for successful venom-specific immunotherapy (VIT). If the clinical history does not allow the identification of the culprit insect, diagnosis is often hampered by positive test results to various venoms. Modern component-resolved diagnostics (CRD) applying marker allergens of Hymenoptera venoms has created new opportunities which facilitate therapeutic decisions and may allow personalized risk stratification for individual patients. Methods: Comprehensive literature search and critical analysis of recently published studies on Hymenoptera venom allergens and CRD. Results and discussion: Changing the research focus from whole venom extracts to individual allergenic molecules led to the development of CRD in HVA. The currently available CRD is a valuable tool to resolve cross-reactivity and primary sensitization, particularly in honeybee and vespid venom allergy. Hence, CRD has simplified therapeutic decisions in case of multiple positive test results, especially in patients who were not able to identify the culprit insect or in cases of discrepancies between clinical history and classical diagnostic results. Moreover, there is first evidence that sensitization to particular allergens might serve as biomarkers to predict risk for severe side-effects during VIT or even for VIT failure. To date, a clear limitation of CRD is the currently available allergen panel which does not allow a definite resolution of allergy to different vespid species such as yellow jackets and European paper wasps.
AB - Background: A comprehensive diagnostic work-up is essential to ensure adequate patient management for the potentially life-threatening condition of Hymenoptera venom allergy (HVA). This includes an unambiguous identification of the allergy-relevant venom as prerequisite for successful venom-specific immunotherapy (VIT). If the clinical history does not allow the identification of the culprit insect, diagnosis is often hampered by positive test results to various venoms. Modern component-resolved diagnostics (CRD) applying marker allergens of Hymenoptera venoms has created new opportunities which facilitate therapeutic decisions and may allow personalized risk stratification for individual patients. Methods: Comprehensive literature search and critical analysis of recently published studies on Hymenoptera venom allergens and CRD. Results and discussion: Changing the research focus from whole venom extracts to individual allergenic molecules led to the development of CRD in HVA. The currently available CRD is a valuable tool to resolve cross-reactivity and primary sensitization, particularly in honeybee and vespid venom allergy. Hence, CRD has simplified therapeutic decisions in case of multiple positive test results, especially in patients who were not able to identify the culprit insect or in cases of discrepancies between clinical history and classical diagnostic results. Moreover, there is first evidence that sensitization to particular allergens might serve as biomarkers to predict risk for severe side-effects during VIT or even for VIT failure. To date, a clear limitation of CRD is the currently available allergen panel which does not allow a definite resolution of allergy to different vespid species such as yellow jackets and European paper wasps.
KW - Component-resolved diagnostics
KW - Hymenoptera venom allergy
KW - Marker allergen
KW - Molecular allergology
KW - Precision medicine
KW - Venom-specific immunotherapy
UR - http://www.scopus.com/inward/record.url?scp=85096102936&partnerID=8YFLogxK
U2 - 10.1007/s40629-020-00151-5
DO - 10.1007/s40629-020-00151-5
M3 - Review article
AN - SCOPUS:85096102936
SN - 2197-0378
VL - 30
SP - 26
EP - 38
JO - Allergo Journal International
JF - Allergo Journal International
IS - 1
ER -