TY - JOUR
T1 - Low seroprotection against diphtheria and tetanus in Lao adolescents
AU - Vantava, Sonephet
AU - Hefele, Lisa
AU - Virachith, Siriphone
AU - Vannachone, Souphaphone
AU - Khounvisith, Vilaysone
AU - Nouanthong, Phonethipsavanh
AU - Hübschen, Judith M.
AU - Sayasone, Somphou
AU - Black, Antony P.
N1 - Funding Information:
This work was supported by the Ministry of Foreign and European Affairs, Luxembourg and the Luxembourg Institute of Health (project ‘Luxembourg‐Laos Partnership for Research and Capacity Building in Infectious Disease Surveillance II’).
Publisher Copyright:
© 2023 The Authors Tropical Medicine & International Health Published by John Wiley & Sons Ltd.
PY - 2023/6
Y1 - 2023/6
N2 - Objectives: There is currently no booster diphtheria or tetanus vaccine for Lao children before adolescence, despite international recommendations. We investigated seroprotection against diphtheria and tetanus among Lao adolescents. Methods: Seven hundred seventy-nine serum samples were tested for anti-diphtheria and anti-tetanus antibodies. Results: Overall, 25.8% of the adolescents had antibody titers corresponding to protection against diphtheria and 30.9% to sufficient immunity against tetanus. Female participants >16 years were more likely to be protected against diphtheria (p < 0.001) and tetanus (p < 0.029). Conclusion: Low protection against diphtheria and tetanus, possibly due to low vaccination coverage or antibody waning, suggests booster doses are warranted before adolescence.
AB - Objectives: There is currently no booster diphtheria or tetanus vaccine for Lao children before adolescence, despite international recommendations. We investigated seroprotection against diphtheria and tetanus among Lao adolescents. Methods: Seven hundred seventy-nine serum samples were tested for anti-diphtheria and anti-tetanus antibodies. Results: Overall, 25.8% of the adolescents had antibody titers corresponding to protection against diphtheria and 30.9% to sufficient immunity against tetanus. Female participants >16 years were more likely to be protected against diphtheria (p < 0.001) and tetanus (p < 0.029). Conclusion: Low protection against diphtheria and tetanus, possibly due to low vaccination coverage or antibody waning, suggests booster doses are warranted before adolescence.
KW - diphtheria
KW - Laos
KW - seroprevalence
KW - tetanus
KW - vaccination
UR - http://www.scopus.com/inward/record.url?scp=85159606736&partnerID=8YFLogxK
UR - https://pubmed.ncbi.nlm.nih.gov/37199458
U2 - 10.1111/tmi.13882
DO - 10.1111/tmi.13882
M3 - Article
C2 - 37199458
SN - 1360-2276
VL - 28
SP - 501
EP - 506
JO - Tropical Medicine and International Health
JF - Tropical Medicine and International Health
IS - 6
ER -