Long-term virological outcome in patients infected with multi- nucleoside analogue-resistant HIV-1

Philippe Clevenbergh*, Myriam Kirstetter, Jean Yves Liotier, Michel Dupon, Patrick Philibert, Christine Jacomet, Eric Cua, Nathalie Montagne, Jean Claude Schmit, Pierre Dellamonica

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Abstract

The emergence of HIV strains that are resistant to antiretroviral drugs is a major cause of treatment failure. Two sets of mutations: the Q151M complex and the 69 insert, cause resistance to multiple nucleoside analogues. We report the response to treatment in 12 patients with multiple NRTI-resistant HIV-1 strains. Seven of 12 patients (58%) were able to maintain a viral load below 200 copies/ml at week 48. The patients most likely to obtain therapeutic success were those having no or low-level resistance to non-nucleoside reverse transcriptase inhibitors and/or protease inhibitors. New and more effective drugs are needed for patients with HIV-1 that is resistant to more than one of the current three classes of HIV drugs.

Original languageEnglish
Pages (from-to)305-308
Number of pages4
JournalAntiviral Therapy
Volume7
Issue number4
Publication statusPublished - Dec 2002
Externally publishedYes

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