Liver Disease and Treatment Needs of Asymptomatic Persons Living With Hepatitis B in Senegal

Adrià Ramírez Mena; Mame Aissé Thioubou; Kalilou Diallo; Judicaël Tine; Ndeye Fatou Ngom; Louise Fortes; Kiné Ndiaye; Jean Claude Karasi; Carole Seguin-Devaux; Henri Goedertz; Daouda Diouf; Moussa Seydi; Benjamin Amaye Sambou; Vic Arendt; Gilles Wandeler; Noël Magloire Manga; for SEN-B and CARES

doi:10.1093/ofid/ofac558

Liver Disease and Treatment Needs of Asymptomatic Persons Living With Hepatitis B in Senegal

Adrià Ramírez Mena, Mame Aissé Thioubou, Kalilou Diallo, Judicaël Tine, Ndeye Fatou Ngom, Louise Fortes, Kiné Ndiaye, Jean Claude Karasi, Carole Seguin-Devaux, Henri Goedertz, Daouda Diouf, Moussa Seydi, Benjamin Amaye Sambou, Vic Arendt, Gilles Wandeler^*, Noël Magloire Manga, for SEN-B and CARES

^*Corresponding author for this work

Infection and Immunotherapy Research

Research output: Contribution to journal › Article › Research › peer-review

2 Citations (Scopus)

Abstract

The prevalence of active hepatitis B among asymptomatic persons remains unclear in Africa. Of 1206 newly diagnosed persons in Senegal, 12.3% had significant fibrosis and 31.3% had hepatitis B virus (HBV) DNA levels >2000 IU/mL. Overall, 128 (12.9%) were eligible for antiviral therapy. Generalized HBV screening allowed the identification of a large population requiring HBV care.

Original language	English
Article number	ofac558
Journal	Open Forum Infectious Diseases
Volume	9
Issue number	11
DOIs	https://doi.org/10.1093/ofid/ofac558
Publication status	Published - 1 Nov 2022

Keywords

hepatitis B
liver fibrosis
Senegal

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10.1093/ofid/ofac558Licence: CC BY-NC-ND

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Ramírez Mena, A., Thioubou, M. A., Diallo, K., Tine, J., Ngom, N. F., Fortes, L., Ndiaye, K., Karasi, J. C., Seguin-Devaux, C., Goedertz, H., Diouf, D., Seydi, M., Sambou, B. A., Arendt, V., Wandeler, G., Manga, N. M., & for SEN-B and CARES (2022). Liver Disease and Treatment Needs of Asymptomatic Persons Living With Hepatitis B in Senegal. Open Forum Infectious Diseases, 9(11), Article ofac558. https://doi.org/10.1093/ofid/ofac558

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title = "Liver Disease and Treatment Needs of Asymptomatic Persons Living With Hepatitis B in Senegal",

abstract = "The prevalence of active hepatitis B among asymptomatic persons remains unclear in Africa. Of 1206 newly diagnosed persons in Senegal, 12.3% had significant fibrosis and 31.3% had hepatitis B virus (HBV) DNA levels >2000 IU/mL. Overall, 128 (12.9%) were eligible for antiviral therapy. Generalized HBV screening allowed the identification of a large population requiring HBV care.",

keywords = "hepatitis B, liver fibrosis, Senegal",

author = "{Ram{\'i}rez Mena}, Adri{\`a} and Thioubou, {Mame Aiss{\'e}} and Kalilou Diallo and Judica{\"e}l Tine and Ngom, {Ndeye Fatou} and Louise Fortes and Kin{\'e} Ndiaye and Karasi, {Jean Claude} and Carole Seguin-Devaux and Henri Goedertz and Daouda Diouf and Moussa Seydi and Sambou, {Benjamin Amaye} and Vic Arendt and Gilles Wandeler and Manga, {No{\"e}l Magloire} and {for SEN-B and CARES}",

note = "Financial support: This work was supported by the Swiss National Science Foundation (PZ00P3_154730); the Minist{\`e}re des Affaires {\'e}trang{\`e}res et europ{\'e}ennes de Luxembourg - Direction de la coop{\'e}ration au d{\'e}veloppement et de l{\textquoteright}action humanitaire; and an investigator-initiated study from Roche Diagnostics. {\textcopyright} The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America.",

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Ramírez Mena, A, Thioubou, MA, Diallo, K, Tine, J, Ngom, NF, Fortes, L, Ndiaye, K, Karasi, JC, Seguin-Devaux, C, Goedertz, H, Diouf, D, Seydi, M, Sambou, BA, Arendt, V, Wandeler, G, Manga, NM & for SEN-B and CARES 2022, 'Liver Disease and Treatment Needs of Asymptomatic Persons Living With Hepatitis B in Senegal', Open Forum Infectious Diseases, vol. 9, no. 11, ofac558. https://doi.org/10.1093/ofid/ofac558

TY - JOUR

T1 - Liver Disease and Treatment Needs of Asymptomatic Persons Living With Hepatitis B in Senegal

AU - Ramírez Mena, Adrià

AU - Thioubou, Mame Aissé

AU - Diallo, Kalilou

AU - Tine, Judicaël

AU - Ngom, Ndeye Fatou

AU - Fortes, Louise

AU - Ndiaye, Kiné

AU - Karasi, Jean Claude

AU - Seguin-Devaux, Carole

AU - Goedertz, Henri

AU - Diouf, Daouda

AU - Seydi, Moussa

AU - Sambou, Benjamin Amaye

AU - Arendt, Vic

AU - Wandeler, Gilles

AU - Manga, Noël Magloire

AU - for SEN-B and CARES

N1 - Financial support: This work was supported by the Swiss National Science Foundation (PZ00P3_154730); the Ministère des Affaires étrangères et européennes de Luxembourg - Direction de la coopération au développement et de l’action humanitaire; and an investigator-initiated study from Roche Diagnostics. © The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

PY - 2022/11/1

Y1 - 2022/11/1

N2 - The prevalence of active hepatitis B among asymptomatic persons remains unclear in Africa. Of 1206 newly diagnosed persons in Senegal, 12.3% had significant fibrosis and 31.3% had hepatitis B virus (HBV) DNA levels >2000 IU/mL. Overall, 128 (12.9%) were eligible for antiviral therapy. Generalized HBV screening allowed the identification of a large population requiring HBV care.

AB - The prevalence of active hepatitis B among asymptomatic persons remains unclear in Africa. Of 1206 newly diagnosed persons in Senegal, 12.3% had significant fibrosis and 31.3% had hepatitis B virus (HBV) DNA levels >2000 IU/mL. Overall, 128 (12.9%) were eligible for antiviral therapy. Generalized HBV screening allowed the identification of a large population requiring HBV care.

KW - hepatitis B

KW - liver fibrosis

KW - Senegal

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UR - https://pubmed.ncbi.nlm.nih.gov/36381617

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DO - 10.1093/ofid/ofac558

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SN - 2328-8957

VL - 9

JO - Open Forum Infectious Diseases

JF - Open Forum Infectious Diseases

IS - 11

M1 - ofac558

ER -

Liver Disease and Treatment Needs of Asymptomatic Persons Living With Hepatitis B in Senegal

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