TY - JOUR
T1 - Lipoprotein(a) and secondary prevention of atherothrombotic events
T2 - A critical appraisal
AU - Boffa, Michael B.
AU - Stranges, Saverio
AU - Klar, Neil
AU - Moriarty, Patrick M.
AU - Watts, Gerald F.
AU - Koschinsky, Marlys L.
N1 - Publisher Copyright:
© 2018
PY - 2018/11/1
Y1 - 2018/11/1
N2 - Elevated plasma concentrations of lipoprotein(a) [Lp(a)] are an independent, and possibly causal, risk factor for atherothrombotic diseases including coronary heart disease. The principal evidence base for this comes from large population studies focusing on first atherothrombotic events. However, inconsistent findings have been reported from studies investigating the impact of elevated Lp(a) on atherothrombotic events in subjects with preexisting cardiovascular disease. This question is very important because the secondary prevention population is recommended for Lp(a) screening by some guidelines and could be an important target group for Lp(a)-lowering therapies that are currently on the horizon. In this review, we survey the secondary prevention literature as it relates to Lp(a) and identify some possible confounding factors that may underlie the inconsistent findings, such as index event bias.
AB - Elevated plasma concentrations of lipoprotein(a) [Lp(a)] are an independent, and possibly causal, risk factor for atherothrombotic diseases including coronary heart disease. The principal evidence base for this comes from large population studies focusing on first atherothrombotic events. However, inconsistent findings have been reported from studies investigating the impact of elevated Lp(a) on atherothrombotic events in subjects with preexisting cardiovascular disease. This question is very important because the secondary prevention population is recommended for Lp(a) screening by some guidelines and could be an important target group for Lp(a)-lowering therapies that are currently on the horizon. In this review, we survey the secondary prevention literature as it relates to Lp(a) and identify some possible confounding factors that may underlie the inconsistent findings, such as index event bias.
KW - Atherothrombotic disease
KW - Clinical studies
KW - Confounding
KW - Coronary heart disease
KW - Epidemiology
KW - Risk factors
UR - http://www.scopus.com/inward/record.url?scp=85054427504&partnerID=8YFLogxK
U2 - 10.1016/j.jacl.2018.08.012
DO - 10.1016/j.jacl.2018.08.012
M3 - Review article
C2 - 30316749
AN - SCOPUS:85054427504
SN - 1933-2874
VL - 12
SP - 1358
EP - 1366
JO - Journal of Clinical Lipidology
JF - Journal of Clinical Lipidology
IS - 6
ER -