TY - JOUR
T1 - Limited diversity of measles field isolates after a National Immunization Day in Burkina Faso
T2 - Progress from endemic to epidemic transmission?
AU - Mulders, Mick N.
AU - Nebie, Yacouba K.
AU - Fack, Fred
AU - Kapitanyuk, Tetyana
AU - Sanou, Oumar
AU - Valéa, Dianne C.
AU - Muyembe-Tamfum, Jean Jacques
AU - Ammerlaan, Wim
AU - Muller, Claude P.
N1 - Funding Information:
Financial support: Ministère des Affaires Etrangères, du Commerce Extérieur, de la Coopération de l’Action Humanitaire et de la Défense, Luxembourg; European Commission 5th Framework Programme (QLK2-CT-2001-01632); Centre Recherche Publique–Santé, Luxembourg; Ministère de la Culture, de l’Enseignement Supérieure et de la Recherche, Luxembourg (fellowship to T.K.).
PY - 2003/5/15
Y1 - 2003/5/15
N2 - Despite recent National Immunization Days in Burkina Faso, the rural province of Houët reported >400 measles cases in 2001 (82% not vaccinated). Phylogenetic analysis of 58 measles virus field isolates plus the first sequences from the Democratic Republic of the Congo and the Republic of Congo are reported. All viruses were genotype B3, which is common in the region. In Houët, there were two geographically confined genetic variants, suggesting two independent importation events. Strain diversity in Houët (1.5%) and the Congos was limited in comparison with Ibadan, Nigeria (4.6%), where measles is endemic. Strain variability, assessed by heteroduplex mobility assay, confirmed these findings. Despite large local pools of susceptible persons even after several rounds of vaccination, the limited strain diversity suggests that parts of rural Burkina Faso may be moving from an endemic to an epidemic transmission pattern of measles virus.
AB - Despite recent National Immunization Days in Burkina Faso, the rural province of Houët reported >400 measles cases in 2001 (82% not vaccinated). Phylogenetic analysis of 58 measles virus field isolates plus the first sequences from the Democratic Republic of the Congo and the Republic of Congo are reported. All viruses were genotype B3, which is common in the region. In Houët, there were two geographically confined genetic variants, suggesting two independent importation events. Strain diversity in Houët (1.5%) and the Congos was limited in comparison with Ibadan, Nigeria (4.6%), where measles is endemic. Strain variability, assessed by heteroduplex mobility assay, confirmed these findings. Despite large local pools of susceptible persons even after several rounds of vaccination, the limited strain diversity suggests that parts of rural Burkina Faso may be moving from an endemic to an epidemic transmission pattern of measles virus.
UR - http://www.scopus.com/inward/record.url?scp=0037904611&partnerID=8YFLogxK
U2 - 10.1086/368036
DO - 10.1086/368036
M3 - Article
C2 - 12721926
AN - SCOPUS:0037904611
SN - 0022-1899
VL - 187
SP - S277-S282
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - SUPPL. 1
ER -