L'hypoxie tumorale

Translated title of the contribution: Tumor hypoxia: A key player in the regulation of stromal and anti-tumor responses

Meriem Hasmim, Yosra Messai, Muhammad Zaeem Noman, Salem Chouaib*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Abstract

Hypoxia is a major feature of most solid tumors. Cells adapt to lower oxygen availability by stabilizing HIF transcription factors, which in turn activate the expression of many genes resulting in the survival and maintenance of cellular functions. In tumor cells, exposure to hypoxic stress results in the activation, via the HIF factors, of a series of genes enabling tumor cells to resist to killing by cytotoxic effectors of the immune system. Tissue hypoxia also controls the functions and differentiation of immune cells. This review describes the hypoxia-induced mechanisms of tumor resistance to killing by cytotoxic effectors, and the functional effects of hypoxia on the immune cells.

Translated title of the contributionTumor hypoxia: A key player in the regulation of stromal and anti-tumor responses
Original languageFrench
Pages (from-to)422-428
Number of pages7
JournalMedecine/Sciences
Volume30
Issue number4
DOIs
Publication statusPublished - Apr 2014
Externally publishedYes

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