Lactate monitoring in organotypic 3D cell cultures

S. Hammer, A. Weltin*, Y. Kaminski, F. Noor, J. Kieninger, G. A. Urban

*Corresponding author for this work

Research output: Contribution to journalConference articlepeer-review

4 Citations (Scopus)


We present an electrochemical metabolic monitoring system, which is combined with a spheroid 3D tumor cell culture environment. It allows the continuous and precise monitoring of lactate production rates of single human hepatocyte spheroids online over days. Lactate concentration was measured using an electrochemical microsensor enabling the real-time monitoring of metabolic rates in combination with drug exposure. This setup can be used for drug testing as a powerful tool for fundamental research in general biology and toxicology.

Original languageEnglish
Pages (from-to)961-964
Number of pages4
JournalProcedia Engineering
Publication statusPublished - 2015
Externally publishedYes
Event29th European Conference on Solid-State Transducers, EUROSENSORS 2015; Freiburg; Germany; 6 September 2015 through 9 September 2015. - Freiburg, Germany
Duration: 6 Sept 20159 Sept 2015


  • 3D cell culture
  • Cancer
  • Electrochemical
  • Lactate
  • Microsensors
  • Monitoring
  • Spheroids
  • Toxicology


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