Lack of polysomnographic Non-REM sleep changes in early Parkinson's disease

Nico J. Diederich*, Olivier Rufra, Vannina Pieri, Géraldine Hipp, Michel Vaillant

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Abstract

Background: Polysomnography (PSG) data are rare in patients who have early stage idiopathic Parkinson's disease (IPD). Methods: Thirty-three patients who had IPD with a disease duration ≤3 years and 37 age-matched controls were recruited. PSG analysis was performed on current medication. Results: Patients with IPD had a reduced mean percentage of muscle atonia during rapid eye movement (REM) sleep (80% vs 93%; P<0.05). Total sleep time, sleep efficiency, indices/hour of arousals, awakenings, apnea/hypopnea, and periodic leg movements were similar in both groups. Age, but not dopaminergic medication, had a negative impact on sleep architecture in patients with IPD. There was no correlation between sleep efficiency assessed by PSG and sleep quality assessed by questionnaire. Conclusions: The results confirmed a reduction in muscle atonia during REM sleep as a characteristic finding in early IPD. However, there were no further disease-inherent or medication-induced changes in sleep architecture. Although sleep disturbances are considered to be an integral part of IPD, PSG cannot yet identify them objectively at an early stage.

Original languageEnglish
Pages (from-to)1443-1446
Number of pages4
JournalMovement Disorders
Volume28
Issue number10
DOIs
Publication statusPublished - Sep 2013

Keywords

  • Parkinson's disease
  • Polysomnography
  • REM sleep behavior disorder
  • Sleep
  • Sleep questionnaire

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