Isolation, characterization, and bioactivity evaluation of 3-((6-methylpyrazin-2-yl)methyl)-1H-indole, a new alkaloid from a deep-sea-derived actinomycete serinicoccus profundi sp. nov.

Xian Wen Yang; Gai Yun Zhang; Jian Xi Ying; Bing Yang; Xue Feng Zhou; Andre Steinmetz; Yong Hong Liu; Ning Wang

doi:10.3390/md11010033

Isolation, characterization, and bioactivity evaluation of 3-((6-methylpyrazin-2-yl)methyl)-1H-indole, a new alkaloid from a deep-sea-derived actinomycete serinicoccus profundi sp. nov.

Xian Wen Yang, Gai Yun Zhang, Jian Xi Ying, Bing Yang, Xue Feng Zhou, Andre Steinmetz, Yong Hong Liu^*, Ning Wang

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

35 Citations (Scopus)

Abstract

One new alkaloid, 3-((6-methylpyrazin-2-yl)methyl)-1H-indole (1) was obtained from the deep-sea actinomycete Serinicoccus profundi sp. nov., along with five known compounds (2-6). Their structures were determined on the basis of detailed analysis of the 1D and 2D NMR as well as MS data. The new indole alkaloid displayed weak antimicrobial activity against Staphylococcus aureus ATCC 25923 with an MIC value of 96 μg/mL. It showed no cytotoxicity on a normal human liver cell line (BEL7402) and a human liver tumor cell line (HL-7702).

Original language	English
Pages (from-to)	33-39
Number of pages	7
Journal	Marine Drugs
Volume	11
Issue number	1
DOIs	https://doi.org/10.3390/md11010033
Publication status	Published - Jan 2013

Keywords

Actinomycete
Alkaloid
Antibacterial activity
Cytotoxicity
Deep-sea sediment
Serinicoccus profundi sp. nov.

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10.3390/md11010033

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title = "Isolation, characterization, and bioactivity evaluation of 3-((6-methylpyrazin-2-yl)methyl)-1H-indole, a new alkaloid from a deep-sea-derived actinomycete serinicoccus profundi sp. nov.",

abstract = "One new alkaloid, 3-((6-methylpyrazin-2-yl)methyl)-1H-indole (1) was obtained from the deep-sea actinomycete Serinicoccus profundi sp. nov., along with five known compounds (2-6). Their structures were determined on the basis of detailed analysis of the 1D and 2D NMR as well as MS data. The new indole alkaloid displayed weak antimicrobial activity against Staphylococcus aureus ATCC 25923 with an MIC value of 96 μg/mL. It showed no cytotoxicity on a normal human liver cell line (BEL7402) and a human liver tumor cell line (HL-7702).",

keywords = "Actinomycete, Alkaloid, Antibacterial activity, Cytotoxicity, Deep-sea sediment, Serinicoccus profundi sp. nov.",

author = "Yang, {Xian Wen} and Zhang, {Gai Yun} and Ying, {Jian Xi} and Bing Yang and Zhou, {Xue Feng} and Andre Steinmetz and Liu, {Yong Hong} and Ning Wang",

year = "2013",

month = jan,

doi = "10.3390/md11010033",

language = "English",

volume = "11",

pages = "33--39",

journal = "Marine Drugs",

issn = "1660-3397",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "1",

}

Isolation, characterization, and bioactivity evaluation of 3-((6-methylpyrazin-2-yl)methyl)-1H-indole, a new alkaloid from a deep-sea-derived actinomycete serinicoccus profundi sp. nov. / Yang, Xian Wen; Zhang, Gai Yun; Ying, Jian Xi et al.
In: Marine Drugs, Vol. 11, No. 1, 01.2013, p. 33-39.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Isolation, characterization, and bioactivity evaluation of 3-((6-methylpyrazin-2-yl)methyl)-1H-indole, a new alkaloid from a deep-sea-derived actinomycete serinicoccus profundi sp. nov.

AU - Yang, Xian Wen

AU - Zhang, Gai Yun

AU - Ying, Jian Xi

AU - Yang, Bing

AU - Zhou, Xue Feng

AU - Steinmetz, Andre

AU - Liu, Yong Hong

AU - Wang, Ning

PY - 2013/1

Y1 - 2013/1

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AB - One new alkaloid, 3-((6-methylpyrazin-2-yl)methyl)-1H-indole (1) was obtained from the deep-sea actinomycete Serinicoccus profundi sp. nov., along with five known compounds (2-6). Their structures were determined on the basis of detailed analysis of the 1D and 2D NMR as well as MS data. The new indole alkaloid displayed weak antimicrobial activity against Staphylococcus aureus ATCC 25923 with an MIC value of 96 μg/mL. It showed no cytotoxicity on a normal human liver cell line (BEL7402) and a human liver tumor cell line (HL-7702).

KW - Actinomycete

KW - Alkaloid

KW - Antibacterial activity

KW - Cytotoxicity

KW - Deep-sea sediment

KW - Serinicoccus profundi sp. nov.

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DO - 10.3390/md11010033

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SN - 1660-3397

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JO - Marine Drugs

JF - Marine Drugs

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Isolation, characterization, and bioactivity evaluation of 3-((6-methylpyrazin-2-yl)methyl)-1H-indole, a new alkaloid from a deep-sea-derived actinomycete serinicoccus profundi sp. nov.

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Keywords

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