Isolation, characterization, and bioactivity evaluation of 3-((6-methylpyrazin-2-yl)methyl)-1H-indole, a new alkaloid from a deep-sea-derived actinomycete serinicoccus profundi sp. nov.

Xian Wen Yang, Gai Yun Zhang, Jian Xi Ying, Bing Yang, Xue Feng Zhou, Andre Steinmetz, Yong Hong Liu*, Ning Wang

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)

Abstract

One new alkaloid, 3-((6-methylpyrazin-2-yl)methyl)-1H-indole (1) was obtained from the deep-sea actinomycete Serinicoccus profundi sp. nov., along with five known compounds (2-6). Their structures were determined on the basis of detailed analysis of the 1D and 2D NMR as well as MS data. The new indole alkaloid displayed weak antimicrobial activity against Staphylococcus aureus ATCC 25923 with an MIC value of 96 μg/mL. It showed no cytotoxicity on a normal human liver cell line (BEL7402) and a human liver tumor cell line (HL-7702).

Original languageEnglish
Pages (from-to)33-39
Number of pages7
JournalMarine Drugs
Volume11
Issue number1
DOIs
Publication statusPublished - Jan 2013

Keywords

  • Actinomycete
  • Alkaloid
  • Antibacterial activity
  • Cytotoxicity
  • Deep-sea sediment
  • Serinicoccus profundi sp. nov.

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