Is the Consensual Threshold for Defining High Glucose Variability Implementable in Clinical Practice?

Jean Baptiste Julla, Pauline Jacquemier, Guy Fagherazzi, Tiphaine Vidal-Trecan, Vanessa Juddoo, Asma Jaziri, Hanane Mersel, Nicolas Venteclef, Ronan Roussel, Pascale Massin, Aude Couturier, Jean François Gautier, Jean Pierre Riveline

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

OBJECTIVE: Estimating glycemic variability (GV) through within-day coefficient of variation (%CVw) is recommended for patients with type 1 Diabetes (T1D). High GV (hGV) is defined as %CVw > 36%. However, continuous glucose monitoring (CGM) devices provide exclusively total CV (%CVT). We aimed to assess consequences of this disparity. RESEARCH DESIGN AND METHODS: We retrospectively calculated both %CVT and %CVw of consecutive T1D patients from their CGM raw data during 14 days. Patients with hGV with %CVT >36% and %CVw ≤36% were called the "inconsistent GV group". RESULTS: A total of 104 patients were included. Mean ± SD %CVT and %CVw were 42.4 ± 8% and 37.0 ± 7.4% respectively (P < 0.0001). Using %CVT, 81 patients (73.6%) were classified as having hGV, whereas 59 (53.6%) using %CVw (P < 0.0001) corresponding to 22 patients (21%) in the inconsistent GV population. CONCLUSIONS: Evaluation of GV through %CV in patients with T1D is highly dependent on the calculation method and then must be standardized.

Original languageEnglish
Pages (from-to)1722-1725
Number of pages4
JournalDiabetes Care
Volume44
Issue number7
Early online date7 Jun 2021
DOIs
Publication statusPublished - 1 Jul 2021

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