TY - JOUR
T1 - Is concordance with World Cancer Research Fund/American Institute for Cancer Research guidelines for cancer prevention related to subsequent risk of cancer? Results from the EPIC study
AU - Romaguera, Dora
AU - Vergnaud, Anne Claire
AU - Peeters, Petra H.
AU - Van Gils, Carla H.
AU - Chan, Doris S.M.
AU - Ferrari, Pietro
AU - Romieu, Isabelle
AU - Jenab, Mazda
AU - Slimani, Nadia
AU - Clavel-Chapelon, Françoise
AU - Fagherazzi, Guy
AU - Perquier, Florence
AU - Kaaks, Rudolf
AU - Teucher, Birgit
AU - Boeing, Heiner
AU - Von Rüsten, Anne
AU - Tjønneland, Anne
AU - Olsen, Anja
AU - Dahm, Christina C.
AU - Overvad, Kim
AU - Quirós, José Ramón
AU - Gonzalez, Carlos A.
AU - Sánchez, María José
AU - Navarro, Carmen
AU - Barricarte, Aurelio
AU - Dorronsoro, Miren
AU - Khaw, Kay Tee
AU - Wareham, Nicholas J.
AU - Crowe, Francesca L.
AU - Key, Timothy J.
AU - Trichopoulou, Antonia
AU - Lagiou, Pagona
AU - Bamia, Christina
AU - Masala, Giovanna
AU - Vineis, Paolo
AU - Tumino, Rosario
AU - Sieri, Sabina
AU - Panico, Salvatore
AU - May, Anne M.
AU - Bueno-de-Mesquita, H. Bas
AU - Büchner, Frederike L.
AU - Wirfält, Elisabet
AU - Manjer, Jonas
AU - Johansson, Ingegerd
AU - Hallmans, Göran
AU - Skeie, Guri
AU - Borch, Kristin Benjaminsen
AU - Parr, Christine L.
AU - Riboli, Elio
AU - Norat, Teresa
PY - 2012/7
Y1 - 2012/7
N2 - Background: In 2007 the World Cancer Research Fund (WCRF) and the American Institute of Cancer Research (AICR) issued 8 recommendations (plus 2 special recommendations) on diet, physical activity, and weight management for cancer prevention on the basis of the most comprehensive collection of available evidence. Objective: We aimed to investigate whether concordance with the WCRF/AICR recommendations was related to cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Design: The present study included 386,355 EPIC participants from 9 European countries. At recruitment, dietary, anthropometric, and lifestyle information was collected. A score was constructed based on the WCRF/AICR recommendations on weight management, physical activity, foods and drinks that promote weight gain, plant foods, animal foods, alcoholic drinks, and breastfeeding for women; the score range was 0-6 for men and 0-7 for women. Higher scores indicated greater concordance with WCRF/AICR recommendations. The association between the score and cancer risk was estimated by using multivariable Cox regression models. Results: Concordance with the score was significantly associated with decreased risk of cancer. A 1-point increment in the score was associated with a risk reduction of 5% (95% CI: 3%, 7%) for total cancer, 12% (95% CI: 9%, 16%) for colorectal cancer, and 16% (95% CI: 9%, 22%) for stomach cancer. Significant associations were also observed for cancers of the breast, endometrium, lung, kidney, upper aerodigestive tract, liver, and esophagus but not for prostate, ovarian, pancreatic, and bladder cancers. Conclusion: Adherence to the WCRF/AICR recommendations for cancer prevention may lower the risk of developing most types of cancer.
AB - Background: In 2007 the World Cancer Research Fund (WCRF) and the American Institute of Cancer Research (AICR) issued 8 recommendations (plus 2 special recommendations) on diet, physical activity, and weight management for cancer prevention on the basis of the most comprehensive collection of available evidence. Objective: We aimed to investigate whether concordance with the WCRF/AICR recommendations was related to cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Design: The present study included 386,355 EPIC participants from 9 European countries. At recruitment, dietary, anthropometric, and lifestyle information was collected. A score was constructed based on the WCRF/AICR recommendations on weight management, physical activity, foods and drinks that promote weight gain, plant foods, animal foods, alcoholic drinks, and breastfeeding for women; the score range was 0-6 for men and 0-7 for women. Higher scores indicated greater concordance with WCRF/AICR recommendations. The association between the score and cancer risk was estimated by using multivariable Cox regression models. Results: Concordance with the score was significantly associated with decreased risk of cancer. A 1-point increment in the score was associated with a risk reduction of 5% (95% CI: 3%, 7%) for total cancer, 12% (95% CI: 9%, 16%) for colorectal cancer, and 16% (95% CI: 9%, 22%) for stomach cancer. Significant associations were also observed for cancers of the breast, endometrium, lung, kidney, upper aerodigestive tract, liver, and esophagus but not for prostate, ovarian, pancreatic, and bladder cancers. Conclusion: Adherence to the WCRF/AICR recommendations for cancer prevention may lower the risk of developing most types of cancer.
UR - http://www.scopus.com/inward/record.url?scp=84863604928&partnerID=8YFLogxK
U2 - 10.3945/ajcn.111.031674
DO - 10.3945/ajcn.111.031674
M3 - Article
C2 - 22592101
AN - SCOPUS:84863604928
SN - 0002-9165
VL - 96
SP - 150
EP - 163
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
IS - 1
ER -