Intracellular pattern-recognition receptors

Catherine Dostert, Etienne Meylan, Jürg Tschopp*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

38 Citations (Scopus)

Abstract

The last ten years of research in the field of innate immunity have been incredibly fertile: the transmembrane Toll-like receptors (TLRs) were discovered as guardians protecting the host against microbial attacks and the emerging pathways characterized in detail. More recently, cytoplasmic sensors were identified, which are capable of detecting not only microbial, but also self molecules. Importantly, while such receptors trigger crucial host responses to microbial insult, over-activity of some of them has been linked to autoinflammatory disorders, hence demonstrating the importance of tightly regulating their actions over time and space. Here, we provide an overview of recent findings covering this area of innate and inflammatory responses that originate from the cytoplasm.

Original languageEnglish
Pages (from-to)830-840
Number of pages11
JournalAdvanced Drug Delivery Reviews
Volume60
Issue number7
DOIs
Publication statusPublished - 29 Apr 2008
Externally publishedYes

Keywords

  • Inflammation
  • Innate immunity
  • Intracellular PRRs
  • Virus recognition

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