TY - JOUR
T1 - Intestinal mucus barrier
T2 - a missing piece of the puzzle in food allergy
AU - Parrish, Amy
AU - Boudaud, Marie
AU - Kuehn, Annette
AU - Ollert, Markus
AU - Desai, Mahesh S.
N1 - Funding Information:
This work was supported by a Fonds National de la Recherche (FNR) CORE grant ( C18/BM/12585940 ) to M.S.D., European Commission Horizon 2020 Marie Skłodowska-Curie individual fellowship to M.B. ( 897408 ), and FNR AFR individual PhD fellowship to A.P. ( 11602973 ).
Publisher Copyright:
© 2021 The Authors
PY - 2022/1
Y1 - 2022/1
N2 - The prevalence of food allergies has reached epidemic levels but the cause remains largely unknown. We discuss the clinical relevance of the gut mucosal barrier as a site for allergic sensitization to food. In this context, we focus on an important but overlooked part of the mucosal barrier in pathogenesis, the glycoprotein-rich mucus layer, and call attention to both beneficial and detrimental aspects of mucus–gut microbiome interactions. Studying the intricate links between the mucus barrier, the associated bacteria, and the mucosal immune system may advance our understanding of the mechanisms and inform prevention and treatment strategies in food allergy.
AB - The prevalence of food allergies has reached epidemic levels but the cause remains largely unknown. We discuss the clinical relevance of the gut mucosal barrier as a site for allergic sensitization to food. In this context, we focus on an important but overlooked part of the mucosal barrier in pathogenesis, the glycoprotein-rich mucus layer, and call attention to both beneficial and detrimental aspects of mucus–gut microbiome interactions. Studying the intricate links between the mucus barrier, the associated bacteria, and the mucosal immune system may advance our understanding of the mechanisms and inform prevention and treatment strategies in food allergy.
KW - allergic sensitization
KW - food allergy
KW - gastrointestinal mucus layer
KW - gut microbiome
KW - mucin-degrading bacteria
KW - mucosal immune system
UR - http://www.scopus.com/inward/record.url?scp=85119495444&partnerID=8YFLogxK
UR - https://www.ncbi.nlm.nih.gov/pubmed/34810087
U2 - 10.1016/j.molmed.2021.10.004
DO - 10.1016/j.molmed.2021.10.004
M3 - Review article
C2 - 34810087
AN - SCOPUS:85119495444
SN - 1471-4914
VL - 28
SP - 36
EP - 50
JO - Trends in Molecular Medicine
JF - Trends in Molecular Medicine
IS - 1
ER -