Interleukin-27 tackles immunosuppression in chronic lymphocytic leukemia

Iria Fernandez Botana, Giulia Pagano, Etienne Moussay*, Jerome Paggetti*

*Corresponding author for this work

Research output: Contribution to journalLetterpeer-review

Abstract

Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in the western world. It is characterized by a high dependency on interactions with the surrounding immune landscape, highlighting its suitability for immune-mediated therapeutic interventions. We recently revealed that the cytokine IL-27 exerts a strong anti-tumor role in CLL through a T-cell-mediated mechanism.

Original languageEnglish
Article number2276490
JournalOncoImmunology
Volume12
Issue number1
DOIs
Publication statusPublished - 3 Nov 2023

Keywords

  • CD8+ T cells
  • Cytokine
  • IL-27
  • immunotherapy
  • leukemia

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