Interleukin-27 tackles immunosuppression in chronic lymphocytic leukemia

Iria Fernandez Botana; Giulia Pagano; Etienne Moussay; Jerome Paggetti

doi:10.1080/2162402X.2023.2276490

Interleukin-27 tackles immunosuppression in chronic lymphocytic leukemia

Iria Fernandez Botana, Giulia Pagano, Etienne Moussay^*, Jerome Paggetti^*

^*Corresponding author for this work

Tumor Stroma Interactions

Research output: Contribution to journal › Letter › peer-review

1 Citation (Scopus)

Abstract

Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in the western world. It is characterized by a high dependency on interactions with the surrounding immune landscape, highlighting its suitability for immune-mediated therapeutic interventions. We recently revealed that the cytokine IL-27 exerts a strong anti-tumor role in CLL through a T-cell-mediated mechanism.

Original language	English
Article number	2276490
Journal	OncoImmunology
Volume	12
Issue number	1
DOIs	https://doi.org/10.1080/2162402X.2023.2276490
Publication status	Published - 3 Nov 2023

Keywords

CD8+ T cells
Cytokine
IL-27
immunotherapy
leukemia

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10.1080/2162402X.2023.2276490Licence: CC BY

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title = "Interleukin-27 tackles immunosuppression in chronic lymphocytic leukemia",

abstract = "Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in the western world. It is characterized by a high dependency on interactions with the surrounding immune landscape, highlighting its suitability for immune-mediated therapeutic interventions. We recently revealed that the cytokine IL-27 exerts a strong anti-tumor role in CLL through a T-cell-mediated mechanism.",

keywords = "CD8+ T cells, Cytokine, IL-27, immunotherapy, leukemia",

author = "{Fernandez Botana}, Iria and Giulia Pagano and Etienne Moussay and Jerome Paggetti",

note = "Publisher Copyright: {\textcopyright} 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.",

year = "2023",

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T1 - Interleukin-27 tackles immunosuppression in chronic lymphocytic leukemia

AU - Fernandez Botana, Iria

AU - Pagano, Giulia

AU - Moussay, Etienne

AU - Paggetti, Jerome

PY - 2023/11/3

Y1 - 2023/11/3

N2 - Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in the western world. It is characterized by a high dependency on interactions with the surrounding immune landscape, highlighting its suitability for immune-mediated therapeutic interventions. We recently revealed that the cytokine IL-27 exerts a strong anti-tumor role in CLL through a T-cell-mediated mechanism.

AB - Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in the western world. It is characterized by a high dependency on interactions with the surrounding immune landscape, highlighting its suitability for immune-mediated therapeutic interventions. We recently revealed that the cytokine IL-27 exerts a strong anti-tumor role in CLL through a T-cell-mediated mechanism.

KW - CD8+ T cells

KW - Cytokine

KW - IL-27

KW - immunotherapy

KW - leukemia

UR - http://www.scopus.com/inward/record.url?scp=85175703004&partnerID=8YFLogxK

UR - https://pubmed.ncbi.nlm.nih.gov/37937211

U2 - 10.1080/2162402X.2023.2276490

DO - 10.1080/2162402X.2023.2276490

M3 - Letter

C2 - 37937211

AN - SCOPUS:85175703004

SN - 2162-4011

VL - 12

JO - OncoImmunology

JF - OncoImmunology

IS - 1

M1 - 2276490

ER -

Interleukin-27 tackles immunosuppression in chronic lymphocytic leukemia

Abstract

Keywords

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