TY - JOUR
T1 - Interactions of commensal and pathogenic microorganisms with the intestinal mucosal barrier
AU - Martens, Eric C.
AU - Neumann, Mareike
AU - Desai, Mahesh S.
N1 - Funding Information:
Work in the authors’ laboratories was supported by National Institutes of Health R01 and R21 (GM099513 and AI128120) awards (to E.C.M.) and an Innovator Award from the Kenneth Rainin Foundation. Work in their laboratories was also supported by the following grants (to M.S.D.): Luxembourg National Research Fund (FNR) CORE (C15/ BM/10318186); FNR AFR Bilateral (11228353); Luxembourg Ministry of Higher Education and Research support (DM-Muc); and Personalized Medicine Consortium of Luxembourg Pump Prime (Die-IBD).
Publisher Copyright:
© 2018 Macmillan Publishers Ltd., part of Springer Nature.
PY - 2018/8/1
Y1 - 2018/8/1
N2 - The intestinal mucosal barrier is composed of epithelial cells that are protected by an overlying host-secreted mucous layer and functions as the first line of defence against pathogenic and non-pathogenic microorganisms. Some microorganisms have evolved strategies to either survive in the mucosal barrier or circumvent it to establish infection. In this Review, we discuss the current state of knowledge of the complex interactions of commensal microorganisms with the intestinal mucosal barrier, and we discuss strategies used by pathogenic microorganisms to establish infection by either exploiting different epithelial cell lineages or disrupting the mucous layer, as well as the role of defects in mucus production in chronic disease.
AB - The intestinal mucosal barrier is composed of epithelial cells that are protected by an overlying host-secreted mucous layer and functions as the first line of defence against pathogenic and non-pathogenic microorganisms. Some microorganisms have evolved strategies to either survive in the mucosal barrier or circumvent it to establish infection. In this Review, we discuss the current state of knowledge of the complex interactions of commensal microorganisms with the intestinal mucosal barrier, and we discuss strategies used by pathogenic microorganisms to establish infection by either exploiting different epithelial cell lineages or disrupting the mucous layer, as well as the role of defects in mucus production in chronic disease.
UR - http://www.scopus.com/inward/record.url?scp=85048546381&partnerID=8YFLogxK
UR - https://pubmed.ncbi.nlm.nih.gov/29904082
U2 - 10.1038/s41579-018-0036-x
DO - 10.1038/s41579-018-0036-x
M3 - Review article
C2 - 29904082
AN - SCOPUS:85048546381
SN - 1740-1526
VL - 16
SP - 457
EP - 470
JO - Nature Reviews Microbiology
JF - Nature Reviews Microbiology
IS - 8
ER -