TY - JOUR
T1 - Interaction between genes and macronutrient intake on the risk of developing type 2 diabetes
T2 - Systematic review and findings from European Prospective Investigation into Cancer (EPIC)-InterAct
AU - Li, Sherly X.
AU - Imamura, Fumiaki
AU - Ye, Zheng
AU - Schulze, Matthias B.
AU - Zheng, Jusheng
AU - Ardanaz, Eva
AU - Arriola, Larraitz
AU - Boeing, Heiner
AU - Dow, Courtney
AU - Fagherazzi, Guy
AU - Franks, Paul W.
AU - Agudo, Antonio
AU - Grioni, Sara
AU - Kaaks, Rudolf
AU - Katzke, Verena A.
AU - Key, Timothy J.
AU - Khaw, Kay Tee
AU - Mancini, Francesca R.
AU - Navarro, Carmen
AU - Nilsson, Peter M.
AU - Onland-Moret, N. Charlotte
AU - Overvad, Kim
AU - Palli, Domenico
AU - Panico, Salvatore
AU - Quirós, J. Ramón
AU - Rolandsson, Olov
AU - Sacerdote, Carlotta
AU - Sánchez, María José
AU - Slimani, Nadia
AU - Sluijs, Ivonne
AU - Spijkerman, Annemieke M.W.
AU - Tjonneland, Anne
AU - Tumino, Rosario
AU - Sharp, Stephen J.
AU - Riboli, Elio
AU - Langenberg, Claudia
AU - Scott, Robert A.
AU - Forouhi, Nita G.
AU - Wareham, Nicholas J.
PY - 2017/7/1
Y1 - 2017/7/1
N2 - Background: Gene-diet interactions have been reported to contribute to the development of type 2 diabetes (T2D). However, to our knowledge, few examples have been consistently replicated to date. Objective: We aimed to identify existing evidence for genemacronutrient interactions and T2D and to examine the reported interactions in a large-scale study. Design: We systematically reviewed studies reporting genemacronutrient interactions and T2D. We searched the MEDLINE, Human Genome Epidemiology Network, and WHO International Clinical Trials Registry Platform electronic databases to identify studies published up to October 2015. Eligibility criteria included assessment of macronutrient quantity (e.g., total carbohydrate) or indicators of quality (e.g., dietary fiber) by use of self-report or objective biomarkers of intake. Interactions identified in the review were subsequently examined in the EPIC (European Prospective Investigation into Cancer)-InterAct case-cohort study (n = 21,148, with 9403 T2D cases; 8 European countries). Prentice-weighted Cox regression was used to estimate countryspecific HRs, 95% CIs, and P-interaction values, which were then pooled by random-effects meta-analysis. A primary model was fitted by using the same covariates as reported in the published studies, and a second model adjusted for additional covariates and estimated the effects of isocaloric macronutrient substitution. Results: Thirteen observational studies met the eligibility criteria (n < 1700 cases). Eight unique interactions were reported to be significant between macronutrients [carbohydrate, fat, saturated fat, dietary fiber, and glycemic load derived from self-report of dietary intake and circulating n-3 (v-3) polyunsaturated fatty acids] and genetic variants in or near transcription factor 7-like 2 (TCF7L2), gastric inhibitory polypeptide receptor (GIPR), caveolin 2 (CAV2), and peptidase D (PEPD) (P-interaction < 0.05). We found no evidence of interaction when we tried to replicate previously reported interactions. In addition, no interactions were detected in models with additional covariates. Conclusions: Eight gene-macronutrient interactions were identified for the risk of T2D from the literature. These interactions were not replicated in the EPIC-InterAct study, which mirrored the analyses undertaken in the original reports. Our findings highlight the importance of independent replication of reported interactions. Am J Clin Nutr 2017;106:263-75.
AB - Background: Gene-diet interactions have been reported to contribute to the development of type 2 diabetes (T2D). However, to our knowledge, few examples have been consistently replicated to date. Objective: We aimed to identify existing evidence for genemacronutrient interactions and T2D and to examine the reported interactions in a large-scale study. Design: We systematically reviewed studies reporting genemacronutrient interactions and T2D. We searched the MEDLINE, Human Genome Epidemiology Network, and WHO International Clinical Trials Registry Platform electronic databases to identify studies published up to October 2015. Eligibility criteria included assessment of macronutrient quantity (e.g., total carbohydrate) or indicators of quality (e.g., dietary fiber) by use of self-report or objective biomarkers of intake. Interactions identified in the review were subsequently examined in the EPIC (European Prospective Investigation into Cancer)-InterAct case-cohort study (n = 21,148, with 9403 T2D cases; 8 European countries). Prentice-weighted Cox regression was used to estimate countryspecific HRs, 95% CIs, and P-interaction values, which were then pooled by random-effects meta-analysis. A primary model was fitted by using the same covariates as reported in the published studies, and a second model adjusted for additional covariates and estimated the effects of isocaloric macronutrient substitution. Results: Thirteen observational studies met the eligibility criteria (n < 1700 cases). Eight unique interactions were reported to be significant between macronutrients [carbohydrate, fat, saturated fat, dietary fiber, and glycemic load derived from self-report of dietary intake and circulating n-3 (v-3) polyunsaturated fatty acids] and genetic variants in or near transcription factor 7-like 2 (TCF7L2), gastric inhibitory polypeptide receptor (GIPR), caveolin 2 (CAV2), and peptidase D (PEPD) (P-interaction < 0.05). We found no evidence of interaction when we tried to replicate previously reported interactions. In addition, no interactions were detected in models with additional covariates. Conclusions: Eight gene-macronutrient interactions were identified for the risk of T2D from the literature. These interactions were not replicated in the EPIC-InterAct study, which mirrored the analyses undertaken in the original reports. Our findings highlight the importance of independent replication of reported interactions. Am J Clin Nutr 2017;106:263-75.
KW - Diabetes
KW - Diet
KW - Effect modification
KW - Gene
KW - Interaction
KW - Macronutrient
KW - Replication
KW - Systematic review
UR - http://www.scopus.com/inward/record.url?scp=85021813265&partnerID=8YFLogxK
U2 - 10.3945/ajcn.116.150094
DO - 10.3945/ajcn.116.150094
M3 - Review article
C2 - 28592605
AN - SCOPUS:85021813265
SN - 0002-9165
VL - 106
SP - 263
EP - 275
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
IS - 1
ER -