TY - JOUR
T1 - Interaction between current Vitamin D supplementation and menopausal hormone therapy use on breast cancer risk
T2 - Evidence from the E3N cohort
AU - Cadeau, Claire
AU - Fournier, Agnès
AU - Mesrine, Sylvie
AU - Clavel-Chapelon, Françoise
AU - Fagherazzi, Guy
AU - Boutron-Ruault, Marie Christine
N1 - Publisher Copyright:
© 2015 American Society for Nutrition.
PY - 2015/10/1
Y1 - 2015/10/1
N2 - Background: Experimental studies suggest protective effects of vitamin D on breast carcinogenesis, particularly on estrogen receptor- positive tumors. Epidemiologic data are less conclusive. Objective: Our objective was to investigate the association between postmenopausal breast cancer risk and current or past vitamin D supplementation overall and according to the use of menopausal hormone therapy (MHT). Design: Between 1995 and 2008, 2482 invasive breast cancer cases were diagnosed among 57,403 postmenopausal women from the E3N prospective cohort during 581,085 person-years. Vitamin D supplementation was assessed from biennially self-administered questionnaires sent in 1995, 2000, 2002, and 2005 and from medicoadministrative data on drug reimbursements since 2004. Multivariable HRs for primary invasive breast cancer and 95% CIs were estimated by using Cox models. Results: A decreased postmenopausal breast cancer risk was associated with current (HR: 0.82; 95% CI: 0.69, 0.97) but not past (HR: 1.10; 95% CI: 0.92, 1.31) vitamin D supplementation (P-homogeneity = 0.02). The association with current vitamin D supplementation differed according to MHT use: ever users (HR: 0.74; 95% CI: 0.60, 0.90) and never users (HR: 1.13; 95% CI: 0.89, 1.56); Phomogeneity = 0.02. Conclusions: In this observational study, current vitamin D supplementation, mostly taken daily and combined with calcium, was associated with a decreased postmenopausal breast cancer risk in MHT users. These findings should be confirmed before considering vitamin D supplementation to partly balance the MHT-associated increased breast cancer risk.
AB - Background: Experimental studies suggest protective effects of vitamin D on breast carcinogenesis, particularly on estrogen receptor- positive tumors. Epidemiologic data are less conclusive. Objective: Our objective was to investigate the association between postmenopausal breast cancer risk and current or past vitamin D supplementation overall and according to the use of menopausal hormone therapy (MHT). Design: Between 1995 and 2008, 2482 invasive breast cancer cases were diagnosed among 57,403 postmenopausal women from the E3N prospective cohort during 581,085 person-years. Vitamin D supplementation was assessed from biennially self-administered questionnaires sent in 1995, 2000, 2002, and 2005 and from medicoadministrative data on drug reimbursements since 2004. Multivariable HRs for primary invasive breast cancer and 95% CIs were estimated by using Cox models. Results: A decreased postmenopausal breast cancer risk was associated with current (HR: 0.82; 95% CI: 0.69, 0.97) but not past (HR: 1.10; 95% CI: 0.92, 1.31) vitamin D supplementation (P-homogeneity = 0.02). The association with current vitamin D supplementation differed according to MHT use: ever users (HR: 0.74; 95% CI: 0.60, 0.90) and never users (HR: 1.13; 95% CI: 0.89, 1.56); Phomogeneity = 0.02. Conclusions: In this observational study, current vitamin D supplementation, mostly taken daily and combined with calcium, was associated with a decreased postmenopausal breast cancer risk in MHT users. These findings should be confirmed before considering vitamin D supplementation to partly balance the MHT-associated increased breast cancer risk.
KW - Breast cancer
KW - Calcitriol
KW - Cohort
KW - Estrogen
KW - MHT
KW - Menopausal hormone therapy
KW - Menopause
KW - Prospective study
KW - Supplements
KW - Vitamin D
UR - http://www.scopus.com/inward/record.url?scp=84942936753&partnerID=8YFLogxK
U2 - 10.3945/ajcn.114.104323
DO - 10.3945/ajcn.114.104323
M3 - Article
C2 - 26354532
AN - SCOPUS:84942936753
SN - 0002-9165
VL - 102
SP - 966
EP - 973
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
IS - 4
ER -