Integration of epigenetic regulatory mechanisms in heart failure

Miron Sopic, Emma L. Robinson, Costanza Emanueli, Prashant Srivastava, Claudio Angione, Carlo Gaetano, Gianluigi Condorelli, Fabio Martelli, Thierry Pedrazzini, Yvan Devaux*, EU-CardioRNA COST Action CA17129 and EU-AtheroNET COST Action CA21153

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)

Abstract

The number of “omics” approaches is continuously growing. Among others, epigenetics has appeared as an attractive area of investigation by the cardiovascular research community, notably considering its association with disease development. Complex diseases such as cardiovascular diseases have to be tackled using methods integrating different omics levels, so called “multi-omics” approaches. These approaches combine and co-analyze different levels of disease regulation. In this review, we present and discuss the role of epigenetic mechanisms in regulating gene expression and provide an integrated view of how these mechanisms are interlinked and regulate the development of cardiac disease, with a particular attention to heart failure. We focus on DNA, histone, and RNA modifications, and discuss the current methods and tools used for data integration and analysis. Enhancing the knowledge of these regulatory mechanisms may lead to novel therapeutic approaches and biomarkers for precision healthcare and improved clinical outcomes.

Original languageEnglish
Article number16
JournalBasic Research in Cardiology
Volume118
Issue number1
DOIs
Publication statusPublished - 4 May 2023

Keywords

  • Data integration
  • Epigenetics
  • Epitranscriptomics
  • Machine learning

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