Intake of coffee, decaffeinated coffee, or tea does not affect risk for pancreatic cancer: Results from the european prospective investigation into nutrition and cancer study

Nirmala Bhoo-Pathy, Cuno S.P.M. Uiterwaal, Vincent K. Dik, Suzanne M. Jeurnink, Bodil H. Bech, Kim Overvad, Jytte Halkjær, Anne Tjønneland, Marie Christine Boutron-Ruault, Guy Fagherazzi, Antoine Racine, Verena A. Katzke, Kuanrong Li, Heiner Boeing, Anna Floegel, Anna Androulidaki, Christina Bamia, Antonia Trichopoulou, Giovanna Masala, Salvatore PanicoPaolo Crosignani, Rosario Tumino, Paolo Vineis, Petra H.M. Peeters, Oxana Gavrilyuk, Guri Skeie, Elisabete Weiderpass, Eric J. Duell, Marcial Arguelles, Esther Molina-Montes, Carmen Navarro, Eva Ardanaz, Miren Dorronsoro, Björn Lindkvist, Peter Wallström, Malin Sund, Weimin Ye, Kay Tee Khaw, Nick Wareham, Timothy J. Key, Ruth C. Travis, Talita Duarte-Salles, Heinz Freisling, Idlir Licaj, Valentina Gallo, Dominique S. Michaud, Elio Riboli, H. Bas Bueno-De-Mesquita*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Abstract

Background & Aims: Few modifiable risk factors have been implicated in the etiology of pancreatic cancer. There is little evidence for the effects of caffeinated coffee, decaffeinated coffee, or tea intake on risk of pancreatic cancer. We investigated the association of total coffee, caffeinated coffee, decaffeinated coffee, and tea consumption with risk of pancreatic cancer. Methods: This study was conducted within the European Prospective Investigation into Nutrition and Cancer cohort, comprising male and female participants from 10 European countries. Between 1992 and 2000, there were 477,312 participants without cancer who completed a dietary questionnaire and were followed up to determine pancreatic cancer incidence. Coffee and tea intake was calibrated with a 24-hour dietary recall. Adjusted hazard ratios (HRs) were computed using multivariable Cox regression. Results: During a mean follow-up period of 11.6 y, 865 first incidences of pancreatic cancers were reported. When divided into fourths, neither total intake of coffee (HR, 1.03; 95% confidence interval [CI], 0.83-1.27; high vs low intake), decaffeinated coffee (HR, 1.12; 95% CI, 0.76-1.63; high vs low intake), nor tea were associated with risk of pancreatic cancer (HR, 1.22, 95% CI, 0.95-1.56; high vs low intake). Moderately low intake of caffeinated coffee was associated with an increased risk of pancreatic cancer (HR, 1.33; 95% CI, 1.02-1.74), compared with low intake. However, no graded dose response was observed, and the association attenuated after restriction to histologically confirmed pancreatic cancers. Conclusions: Based on an analysis of data from the European Prospective Investigation into Nutrition and Cancer cohort, total coffee, decaffeinated coffee, and tea consumption are not related to the risk of pancreatic cancer.

Original languageEnglish
Pages (from-to)1486-1492
Number of pages7
JournalClinical Gastroenterology and Hepatology
Volume11
Issue number11
DOIs
Publication statusPublished - Nov 2013
Externally publishedYes

Keywords

  • Caffeinated Coffee
  • Decaffeinated Coffee
  • Pancreatic Cancer
  • Tea

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