TY - JOUR
T1 - Intake of coffee, decaffeinated coffee, or tea does not affect risk for pancreatic cancer
T2 - Results from the european prospective investigation into nutrition and cancer study
AU - Bhoo-Pathy, Nirmala
AU - Uiterwaal, Cuno S.P.M.
AU - Dik, Vincent K.
AU - Jeurnink, Suzanne M.
AU - Bech, Bodil H.
AU - Overvad, Kim
AU - Halkjær, Jytte
AU - Tjønneland, Anne
AU - Boutron-Ruault, Marie Christine
AU - Fagherazzi, Guy
AU - Racine, Antoine
AU - Katzke, Verena A.
AU - Li, Kuanrong
AU - Boeing, Heiner
AU - Floegel, Anna
AU - Androulidaki, Anna
AU - Bamia, Christina
AU - Trichopoulou, Antonia
AU - Masala, Giovanna
AU - Panico, Salvatore
AU - Crosignani, Paolo
AU - Tumino, Rosario
AU - Vineis, Paolo
AU - Peeters, Petra H.M.
AU - Gavrilyuk, Oxana
AU - Skeie, Guri
AU - Weiderpass, Elisabete
AU - Duell, Eric J.
AU - Arguelles, Marcial
AU - Molina-Montes, Esther
AU - Navarro, Carmen
AU - Ardanaz, Eva
AU - Dorronsoro, Miren
AU - Lindkvist, Björn
AU - Wallström, Peter
AU - Sund, Malin
AU - Ye, Weimin
AU - Khaw, Kay Tee
AU - Wareham, Nick
AU - Key, Timothy J.
AU - Travis, Ruth C.
AU - Duarte-Salles, Talita
AU - Freisling, Heinz
AU - Licaj, Idlir
AU - Gallo, Valentina
AU - Michaud, Dominique S.
AU - Riboli, Elio
AU - Bueno-De-Mesquita, H. Bas
N1 - Funding Information:
Funding Supported by the European Commission (DG-SANCO) and the International Agency for Research on Cancer . The national cohorts are supported by the Danish Cancer Society (Denmark), Ligue contre le Cancer, 3M, Mutuelle Générale de l’Education Nationale, Institut National de la Santé et de la Recherche Medicale (France), Deutsche Krebshilfe, Deutsches Krebsforschungszentrum and Federal Ministry of Education and Research (Germany), Hellenic Health Foundation (Greece), Italian Association for Research on Cancer, National Research Council (Italy), Dutch Ministry of Public Health, Welfare and Sports, Netherlands Cancer Registry, LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund, Statistics Netherlands (The Netherlands), Norwegian Cancer Society (Norway), Health Research Fund, regional governments of Andalucía, Asturias, Basque Country, Murcia, and Navarra , ISCIII RETIC (grant RD06/0020 ) (Spain), Swedish Cancer Society, Swedish Scientific Council, regional government of Skåne and Västerbotten (Sweden), Cancer Research UK, and the Medical Research Council (United Kingdom). Also supported by the European Union, AsiaLink program (grant MY/AsiaLink/044 [128-713] ), and the Ministry of Higher Education, Malaysia (High Impact Research Grant UM.C/HIR/MOHE/06 ) (N.B.-P.).
PY - 2013/11
Y1 - 2013/11
N2 - Background & Aims: Few modifiable risk factors have been implicated in the etiology of pancreatic cancer. There is little evidence for the effects of caffeinated coffee, decaffeinated coffee, or tea intake on risk of pancreatic cancer. We investigated the association of total coffee, caffeinated coffee, decaffeinated coffee, and tea consumption with risk of pancreatic cancer. Methods: This study was conducted within the European Prospective Investigation into Nutrition and Cancer cohort, comprising male and female participants from 10 European countries. Between 1992 and 2000, there were 477,312 participants without cancer who completed a dietary questionnaire and were followed up to determine pancreatic cancer incidence. Coffee and tea intake was calibrated with a 24-hour dietary recall. Adjusted hazard ratios (HRs) were computed using multivariable Cox regression. Results: During a mean follow-up period of 11.6 y, 865 first incidences of pancreatic cancers were reported. When divided into fourths, neither total intake of coffee (HR, 1.03; 95% confidence interval [CI], 0.83-1.27; high vs low intake), decaffeinated coffee (HR, 1.12; 95% CI, 0.76-1.63; high vs low intake), nor tea were associated with risk of pancreatic cancer (HR, 1.22, 95% CI, 0.95-1.56; high vs low intake). Moderately low intake of caffeinated coffee was associated with an increased risk of pancreatic cancer (HR, 1.33; 95% CI, 1.02-1.74), compared with low intake. However, no graded dose response was observed, and the association attenuated after restriction to histologically confirmed pancreatic cancers. Conclusions: Based on an analysis of data from the European Prospective Investigation into Nutrition and Cancer cohort, total coffee, decaffeinated coffee, and tea consumption are not related to the risk of pancreatic cancer.
AB - Background & Aims: Few modifiable risk factors have been implicated in the etiology of pancreatic cancer. There is little evidence for the effects of caffeinated coffee, decaffeinated coffee, or tea intake on risk of pancreatic cancer. We investigated the association of total coffee, caffeinated coffee, decaffeinated coffee, and tea consumption with risk of pancreatic cancer. Methods: This study was conducted within the European Prospective Investigation into Nutrition and Cancer cohort, comprising male and female participants from 10 European countries. Between 1992 and 2000, there were 477,312 participants without cancer who completed a dietary questionnaire and were followed up to determine pancreatic cancer incidence. Coffee and tea intake was calibrated with a 24-hour dietary recall. Adjusted hazard ratios (HRs) were computed using multivariable Cox regression. Results: During a mean follow-up period of 11.6 y, 865 first incidences of pancreatic cancers were reported. When divided into fourths, neither total intake of coffee (HR, 1.03; 95% confidence interval [CI], 0.83-1.27; high vs low intake), decaffeinated coffee (HR, 1.12; 95% CI, 0.76-1.63; high vs low intake), nor tea were associated with risk of pancreatic cancer (HR, 1.22, 95% CI, 0.95-1.56; high vs low intake). Moderately low intake of caffeinated coffee was associated with an increased risk of pancreatic cancer (HR, 1.33; 95% CI, 1.02-1.74), compared with low intake. However, no graded dose response was observed, and the association attenuated after restriction to histologically confirmed pancreatic cancers. Conclusions: Based on an analysis of data from the European Prospective Investigation into Nutrition and Cancer cohort, total coffee, decaffeinated coffee, and tea consumption are not related to the risk of pancreatic cancer.
KW - Caffeinated Coffee
KW - Decaffeinated Coffee
KW - Pancreatic Cancer
KW - Tea
UR - http://www.scopus.com/inward/record.url?scp=84885764411&partnerID=8YFLogxK
U2 - 10.1016/j.cgh.2013.05.029
DO - 10.1016/j.cgh.2013.05.029
M3 - Article
C2 - 23756220
AN - SCOPUS:84885764411
SN - 1542-3565
VL - 11
SP - 1486
EP - 1492
JO - Clinical Gastroenterology and Hepatology
JF - Clinical Gastroenterology and Hepatology
IS - 11
ER -