Innovations in phenotyping of mouse models in the German Mouse Clinic

Helmut Fuchs, Valérie Gailus-Durner, Susanne Neschen, Thure Adler, Luciana Caminha Afonso, Juan Antonio Aguilar-Pimentel, Lore Becker, Alexander Bohla, Julia Calzada-Wack, Christian Cohrs, Anna Dewert, Barbara Fridrich, Lillian Garrett, Lisa Glasl, Alexander Götz, Wolfgang Hans, Sabine M. Hölter, Marion Horsch, Anja Hurt, Eva JanasDirk Janik, Melanie Kahle, Martin Kistler, Tanja Klein-Rodewald, Christoph Lengger, Tonia Ludwig, Holger Maier, Susan Marschall, Kateryna Micklich, Gabriele Möller, Beatrix Naton, Cornelia Prehn, Oliver Puk, Ildikó Rácz, Michael Räß, Birgit Rathkolb, Jan Rozman, Markus Scheerer, Evelyn Schiller, Anja Schrewe, Ralph Steinkamp, Claudia Stöger, Minxuan Sun, Wilfried Szymczak, Irina Treise, Ingrid Liliana Vargas Panesso, Alexandra M. Vernaleken, Monja Willershäuser, Annemarie Wolff-Muscate, Ramona Zeh, Jerzy Adamski, Johannes Beckers, Raffi Bekeredjian, Dirk H. Busch, Oliver Eickelberg, Jack Favor, Jochen Graw, Heinz Höfler, Christoph Höschen, Hugo Katus, Martin Klingenspor, Thomas Klopstock, Frauke Neff, Markus Ollert, Holger Schulz, Tobias Stöger, Eckhard Wolf, Wolfgang Wurst, Ali Önder Yildirim, Andreas Zimmer, Martin Hrabě De Angelis*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)

Abstract

Under the label of the German Mouse Clinic (GMC), a concept has been developed and implemented that allows the better understanding of human diseases on the pathophysiological and molecular level. This includes better understanding of the crosstalk between different organs, pleiotropy of genes, and the systemic impact of envirotypes and drugs. In the GMC, experts from various fields of mouse genetics and physiology, in close collaboration with clinicians, work side by side under one roof. The GMC is an open-access platform for the scientific community by providing phenotypic analysis in bilateral collaborations ("bottom-up projects") and as a partner and driver in international large-scale biology projects ("topdown projects"). Furthermore, technology development is a major topic in the GMC. Innovative techniques for primary and secondary screens are developed and implemented into the phenotyping pipelines (e.g., detection of volatile organic compounds, VOCs).

Original languageEnglish
Pages (from-to)611-622
Number of pages12
JournalMammalian Genome
Volume23
Issue number9-10
DOIs
Publication statusPublished - Oct 2012
Externally publishedYes

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