Innate and adaptive effects of inflammasomes on T cell responses

Catherine Dostert, Kristina Ludigs, Greta Guarda*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

38 Citations (Scopus)


Inflammasomes are protein complexes that form in response to pathogen-derived or host-derived stress signals. Their activation leads to the production of inflammatory cytokines and promotes a pyrogenic cell death process. The massive release of inflammatory mediators that follows inflammasome activation is a key event in alarming innate immune cells. Growing evidence also highlights the role of inflammasome-dependent cytokines in shaping the adaptive immune response, as exemplified by the capacity of IL-1β to support Th17 responses, or by the finding that IL-18 evokes antigen-independent IFN-γ secretion by memory CD8+ T cells. A deeper understanding of these mechanisms and on how to manipulate this powerful inflammatory system therefore represents an important step forward in the development of improved vaccine strategies.

Original languageEnglish
Pages (from-to)359-365
Number of pages7
JournalCurrent Opinion in Immunology
Issue number3
Publication statusPublished - Jun 2013
Externally publishedYes


Dive into the research topics of 'Innate and adaptive effects of inflammasomes on T cell responses'. Together they form a unique fingerprint.

Cite this