Inhibition of MYC translation through targeting of the newly identified PHB-eIF4F complex as a therapeutic strategy in CLL

Biochemistry, Genetics and Molecular Biology

• Carcinogenesis 50%
• Cell Cycle 50%
• Cell Metabolism 50%
• Drug Binding 50%
• Eukaryotic Initiation Factor 50%
• Messenger RNA 100%
• Metabolic Pathway 50%
• Mitogen-Activated Protein Kinase 50%
• Oncogene 100%
• Prohibitin 100%
• RNA Translation 50%
• Translation Initiation 50%
• Translation Regulation 50%
• Untranslated Region 50%

Immunology and Microbiology

• Cell Cycle 50%
• Cell Line 50%
• Cell Metabolism 50%
• Drug Binding 50%
• Immunotherapy 50%
• Initiation Factor 4F 100%
• Leukemia Cell 100%
• Oncogene 100%
• Ribonucleic Acid 100%
• RNA Translation 50%
• Translation Initiation 50%
• Translation Regulation 50%
• Untranslated Region 50%

Keyphrases

• 5′-untranslated Region (5′-UTR) 16%
• Cell Surface Display 16%
• Chronic Lymphocytic Leukemia 100%
• Chronic Lymphocytic Leukemia Cells 33%
• Clinical Parameters 16%
• Dysregulation 16%
• Eukaryotic Initiation Factor 16%
• Flavagline 16%
• High-level Expression 16%
• In Cancer 16%
• Knockdown 16%
• Messenger RNA (mRNA) 16%
• Messenger RNA Processing 16%
• Metabolism 33%
• Mitogen-activated Protein Kinase 16%
• Multi-omics Analysis 16%
• MYC Oncogene 33%
• New Therapeutics 16%
• Oncogenic Pathways 16%
• Poor Survival 16%
• Preferential Translation 16%
• Prohibitin 100%
• Proliferation Arrest 16%
• Therapeutic Potential 16%
• Therapeutic Strategies 100%
• Translation Inhibition 33%
• Translation Initiation 16%
• Translation Rate 16%
• Translation Regulation 16%