Inherent difficulties with active control equivalence studies

Stephen Senn*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)


A simple model is used to investigate the relevance of ‘competence’ to active control equivalence studies )ACES(. It is shown that to the extent that such trials are successful the results of such trials must raise doubts regarding their competence. ACES are thus more problematic than classical clinical trials and the problems with such studies cannot be solved simply by exchanging the usual roles of null and alternative hypotheses.

Original languageEnglish
Pages (from-to)2367-2375
Number of pages9
JournalStatistics in Medicine
Issue number24
Publication statusPublished - 30 Dec 1993
Externally publishedYes


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