Influence of common preanalytical variations on the metabolic profile of serum samples in biobanks

Ophélie Fliniaux, Gwenaelle Gaillard, Antoine Lion, Dominique Cailleu, François Mesnard*, Fotini Betsou

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

Abstract

A blood pre-centrifugation delay of 24 h at room temperature influenced the proton NMR spectroscopic profiles of human serum. A blood pre-centrifugation delay of 24 h at 4°C did not influence the spectroscopic profile as compared with 4 h delays at either room temperature or 4°C. Five or ten serum freeze-thaw cycles also influenced the proton NMR spectroscopic profiles. Certain common in vitro preanalytical variations occurring in biobanks may impact the metabolic profile of human serum.

Original languageEnglish
Pages (from-to)457-465
Number of pages9
JournalJournal of Biomolecular NMR
Volume51
Issue number4
DOIs
Publication statusPublished - Dec 2011
Externally publishedYes

Keywords

  • Biobank
  • Biomarker
  • Biospecimen research
  • Metabolic profiling
  • Preanalytical variation
  • Proton NMR
  • Serum

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