Inflammatory myofibroblastic tumor of the ulnar nerve. Case report and review of the literature

Jens Schittenhelm, Jan Kaminsky, Richard Meyermann, Michel Mittelbronn*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)


Inflammatory myofibroblastic tumors with involvement of cranial and peripheral nerves are exceedingly rare. The authors present the case of a 67-year-old man with an inflammatory myofibroblastic tumor of the left ulnar nerve, which was identified intraoperatively and mimicked a malignant neoplastic lesion. Histopathological examination revealed loosely structured fibrous tissue and collagen deposits intermingled with patchy infiltrates of lymphocytes, plasma cells, and histiocytes penetrating the endo- and epineurium of the affected nerve fascicles. There was strong expression of vimentin and actin in spindle cells throughout the lesion. The histiocytes were CD68- and major histocompatibility complex class II-positive, but lacked CD1a expression. A review of the literature revealed nine histopathologically confirmed cases of inflammatory myofibroblastic tumors involving peripheral or cranial nerves in which slight differences in histopathological features and surgical management were found, which are discussed here.

Original languageEnglish
Pages (from-to)1075-1079
Number of pages5
JournalJournal of Neurosurgery
Issue number6
Publication statusPublished - Jun 2007
Externally publishedYes


  • Inflammatory myofibroblastic tumor
  • Peripheral nervous system
  • Plasma cell granuloma
  • Pseudotumor


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