Induction of allergen-specifi Tregs prior to oral or sublingual immunotherapy of food allergy

Reinhard Bredehorst; Thomas Grunwald; Cathy Léonard; Markus Ollert

Induction of allergen-specifi Tregs prior to oral or sublingual immunotherapy of food allergy

Reinhard Bredehorst (Inventor)
, Thomas Grunwald (Inventor)
, Cathy Léonard (Inventor)
, Markus Ollert (Inventor)

Research output: Patent

Abstract

The present invention relates to methods for the induction of food tolerance by a combination of subcutaneous hydrogel-based immunotherapy with food allergen-derived T cell peptides in the presence of tolerance-promoting concentrations of oligodeoxy-nucleotides with CpG or GpC or GpG motifs (Phase A) and subsequent oral or sublingual immunotherapy with natural or recombinant food allergens (Phase B)

Original language	English
IPC	WO 2019/076477
Publication status	Published - 25 Apr 2019

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title = "Induction of allergen-specifi Tregs prior to oral or sublingual immunotherapy of food allergy",

abstract = "The present invention relates to methods for the induction of food tolerance by a combination of subcutaneous hydrogel-based immunotherapy with food allergen-derived T cell peptides in the presence of tolerance-promoting concentrations of oligodeoxy-nucleotides with CpG or GpC or GpG motifs (Phase A) and subsequent oral or sublingual immunotherapy with natural or recombinant food allergens (Phase B)",

author = "Reinhard Bredehorst and Thomas Grunwald and Cathy L{\'e}onard and Markus Ollert",

year = "2019",

month = apr,

day = "25",

language = "English",

type = "Patent",

note = "WO 2019/076477",

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TY - PAT

T1 - Induction of allergen-specifi Tregs prior to oral or sublingual immunotherapy of food allergy

AU - Bredehorst, Reinhard

AU - Grunwald, Thomas

AU - Léonard, Cathy

AU - Ollert, Markus

PY - 2019/4/25

Y1 - 2019/4/25

N2 - The present invention relates to methods for the induction of food tolerance by a combination of subcutaneous hydrogel-based immunotherapy with food allergen-derived T cell peptides in the presence of tolerance-promoting concentrations of oligodeoxy-nucleotides with CpG or GpC or GpG motifs (Phase A) and subsequent oral or sublingual immunotherapy with natural or recombinant food allergens (Phase B)

AB - The present invention relates to methods for the induction of food tolerance by a combination of subcutaneous hydrogel-based immunotherapy with food allergen-derived T cell peptides in the presence of tolerance-promoting concentrations of oligodeoxy-nucleotides with CpG or GpC or GpG motifs (Phase A) and subsequent oral or sublingual immunotherapy with natural or recombinant food allergens (Phase B)

M3 - Patent

ER -

Induction of allergen-specifi Tregs prior to oral or sublingual immunotherapy of food allergy

Abstract

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