TY - JOUR
T1 - Incorporation of Fast-Elimination Chemicals in Hair Is Governed by Pharmacokinetics-Implications for Exposure Assessment
AU - Faÿs, François
AU - Palazzi, Paul
AU - Zeman, Florence
AU - Hardy, Emilie M.
AU - Schaeffer, Charline
AU - Rousselle, Christophe
AU - Beausoleil, Claire
AU - Appenzeller, Brice M.R.
N1 - Funding Information:
F.F. benefited from a Ph.D. grant from the Luxembourg National Research Fund (Fonds National de la Recherche [FNR]) (AFR16 11262468), Luxembourg. This study was cofunded by ANSES (French Agency for Food, Environmental and Occupational Health & Safety) in the framework of a Research and Development Collaboration.
Publisher Copyright:
© 2023 American Chemical Society.
PY - 2023/5/16
Y1 - 2023/5/16
N2 - Mechanisms governing chemicals’ incorporation in hair are incompletely understood, and gaps remain to link the concentration of chemicals in hair to level of exposure and internal dose present in the body. This study assesses the relevance of hair analysis for the biomonitoring of exposure to fast-elimination compounds and investigates the role of pharmacokinetics (PK) in their incorporation in hair. Rats were administered with pesticides, bisphenols, phthalates, and DINCH over 2 months. Hairs were analyzed for 28 chemicals/metabolites to investigate correlations between their concentration in hair and the dose administered to the animals. Urine collected over 24 h after gavage was used to determine chemicals’ PK and to investigate their influence on incorporation into hair by means of linear mixed models (LMMs). Eighteen chemicals presented a significant correlation between concentration in hair and level of exposure. In models combining all chemicals, agreement between concentration in hair predicted by LMM and experimental values was moderate (R2 = 0.19) but significantly increased when PK were included in the models (R2 = 0.37), and even more when chemical families were considered separately (e.g., R2 = 0.98 for pesticides). This study shows that pharmacokinetics mediate incorporation of chemicals in hair and suggests the relevance of hair for assessing exposure to fast-elimination chemicals.
AB - Mechanisms governing chemicals’ incorporation in hair are incompletely understood, and gaps remain to link the concentration of chemicals in hair to level of exposure and internal dose present in the body. This study assesses the relevance of hair analysis for the biomonitoring of exposure to fast-elimination compounds and investigates the role of pharmacokinetics (PK) in their incorporation in hair. Rats were administered with pesticides, bisphenols, phthalates, and DINCH over 2 months. Hairs were analyzed for 28 chemicals/metabolites to investigate correlations between their concentration in hair and the dose administered to the animals. Urine collected over 24 h after gavage was used to determine chemicals’ PK and to investigate their influence on incorporation into hair by means of linear mixed models (LMMs). Eighteen chemicals presented a significant correlation between concentration in hair and level of exposure. In models combining all chemicals, agreement between concentration in hair predicted by LMM and experimental values was moderate (R2 = 0.19) but significantly increased when PK were included in the models (R2 = 0.37), and even more when chemical families were considered separately (e.g., R2 = 0.98 for pesticides). This study shows that pharmacokinetics mediate incorporation of chemicals in hair and suggests the relevance of hair for assessing exposure to fast-elimination chemicals.
KW - Exposure assessment
KW - Fast-elimination chemicals
KW - Hair
KW - Pharmacokinetics
KW - Urine
UR - http://www.scopus.com/inward/record.url?scp=85159637573&partnerID=8YFLogxK
UR - https://pubmed.ncbi.nlm.nih.gov/37146304
U2 - 10.1021/acs.est.2c06777
DO - 10.1021/acs.est.2c06777
M3 - Article
C2 - 37146304
SN - 0013-936X
VL - 57
SP - 7336
EP - 7345
JO - Environmental Science & Technology
JF - Environmental Science & Technology
IS - 19
ER -