In vivo models of primary brain tumors: Pitfalls and perspectives

Peter C. Huszthy, Inderjit Daphu, Simone P. Niclou, Daniel Stieber, Janice M. Nigro, Per O. Sakariassen, Hrvoje Miletic, Frits Thorsen, Rolf Bjerkvig*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

165 Citations (Scopus)

Abstract

Animal modeling for primary brain tumors has undergone constant development over the last 60 years, and significant improvements have been made recently with the establishment of highly invasive glioblastoma models. In this review we discuss the advantages and pitfalls of model development, focusing on chemically induced models, various xenogeneic grafts of human cell lines, including stem celllike cell lines and biopsy spheroids. We then discuss the development of numerous genetically engineered models available to study mechanisms of tumor initiation and progression. At present it is clear that none of the current animal models fully reflects human gliomas. Yet, the various model systems have provided important insight into specific mechanisms of tumor development. In particular, it is anticipated that a combined comprehensive knowledge of the various models currently available will provide important new knowledge on target identification and the validation and development of new therapeutic strategies.

Original languageEnglish
Pages (from-to)979-993
Number of pages15
JournalNeuro-Oncology
Volume14
Issue number8
DOIs
Publication statusPublished - Aug 2012

Keywords

  • animal models
  • brain tumor development

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